"Deoxyribonuclease I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyzes endonucleolytic cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enzyme has a preference for double-stranded DNA.
| Descriptor ID |
D003850
|
| MeSH Number(s) |
D08.811.277.352.335.350.250
|
| Concept/Terms |
Deoxyribonuclease I- Deoxyribonuclease I
- DNAase I
- Pancreatic DNase
- DNase, Pancreatic
- Thymonuclease
- DNA Endonuclease
- Endonuclease, DNA
- DNase I
Nickase- Nickase
- DNA Nicking Enzyme
- Endonuclease I
|
Below are MeSH descriptors whose meaning is more general than "Deoxyribonuclease I".
Below are MeSH descriptors whose meaning is more specific than "Deoxyribonuclease I".
This graph shows the total number of publications written about "Deoxyribonuclease I" by people in this website by year, and whether "Deoxyribonuclease I" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 3 | 4 |
| 1995 | 1 | 2 | 3 |
| 1996 | 0 | 2 | 2 |
| 1997 | 1 | 3 | 4 |
| 1999 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Deoxyribonuclease I" by people in Profiles.
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Identification of constrained sequence elements across 239 primate genomes. Nature. 2024 Jan; 625(7996):735-742.
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Expanded encyclopaedias of DNA elements in the human and mouse genomes. Nature. 2020 07; 583(7818):699-710.
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Systematic analyses of regulatory variants in DNase I hypersensitive sites identified two novel lung cancer susceptibility loci. Carcinogenesis. 2019 05 14; 40(3):432-440.
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Questions about NgAgo. Protein Cell. 2016 12; 7(12):913-915.
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Structural characterization of the virulence factor Sda1 nuclease from Streptococcus pyogenes. Nucleic Acids Res. 2016 05 05; 44(8):3946-57.
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Long interspersed element-1 protein expression is a hallmark of many human cancers. Am J Pathol. 2014 May; 184(5):1280-6.
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C/EBPa poises B cells for rapid reprogramming into induced pluripotent stem cells. Nature. 2014 Feb 13; 506(7487):235-9.
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An integrated encyclopedia of DNA elements in the human genome. Nature. 2012 Sep 06; 489(7414):57-74.
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An epigenetic chromatin remodeling role for NFATc1 in transcriptional regulation of growth and survival genes in diffuse large B-cell lymphomas. Blood. 2010 Nov 11; 116(19):3899-906.
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A novel Alu-mediated Xq28 microdeletion ablates TAZ and partially deletes DNL1L in a patient with Barth syndrome. Am J Med Genet A. 2009 May; 149A(5):1082-5.