Nicotinamide-Nucleotide Adenylyltransferase
"Nicotinamide-Nucleotide Adenylyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes reversibly the transfer of the adenylyl moiety of ATP to the phosphoryl group of NMN to form NAD+ and pyrophosphate. The enzyme is found predominantly in the nuclei and catalyzes the final reaction in the major pathway for the biosynthesis of NAD in mammals.
| Descriptor ID |
D009612
|
| MeSH Number(s) |
D08.811.913.696.445.600 D12.776.157.687.499 D12.776.660.720.499
|
| Concept/Terms |
Nicotinamide-Nucleotide Adenylyltransferase- Nicotinamide-Nucleotide Adenylyltransferase
- Adenylyltransferase, Nicotinamide-Nucleotide
- Nicotinamide Nucleotide Adenylyltransferase
- NMN Adenylyltransferase
- Adenylyltransferase, NMN
- Nicotinamide Mononucleotide Adenylyltransferase
- Adenylyltransferase, Nicotinamide Mononucleotide
- Mononucleotide Adenylyltransferase, Nicotinamide
- ATP-NMN Adenylyltransferase
- ATP NMN Adenylyltransferase
- Adenylyltransferase, ATP-NMN
- NAD Pyrophosphorylase
- Pyrophosphorylase, NAD
|
Below are MeSH descriptors whose meaning is more general than "Nicotinamide-Nucleotide Adenylyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Nicotinamide-Nucleotide Adenylyltransferase".
This graph shows the total number of publications written about "Nicotinamide-Nucleotide Adenylyltransferase" by people in this website by year, and whether "Nicotinamide-Nucleotide Adenylyltransferase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 2 | 0 | 2 |
| 2016 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Nicotinamide-Nucleotide Adenylyltransferase" by people in Profiles.
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Nuclear NAD+ homeostasis governed by NMNAT1 prevents apoptosis of acute myeloid leukemia stem cells. Sci Adv. 2021 07; 7(30).
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An Alu-mediated duplication in NMNAT1, involved in NAD biosynthesis, causes a novel syndrome, SHILCA, affecting multiple tissues and organs. Hum Mol Genet. 2020 08 03; 29(13):2250-2260.
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NMNAT1 E257K variant, associated with Leber Congenital Amaurosis (LCA9), causes a mild retinal degeneration phenotype. Exp Eye Res. 2018 08; 173:32-43.
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NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies. PLoS Biol. 2016 06; 14(6):e1002472.
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Nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2) regulates axon integrity in the mouse embryo. PLoS One. 2012; 7(10):e47869.
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NMNAT1 mutations cause Leber congenital amaurosis. Nat Genet. 2012 Sep; 44(9):1040-5.
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Mutations in NMNAT1 cause Leber congenital amaurosis and identify a new disease pathway for retinal degeneration. Nat Genet. 2012 Sep; 44(9):1035-9.
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CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy. Hum Mol Genet. 2012 Jan 15; 21(2):251-67.
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NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration. Nature. 2008 Apr 17; 452(7189):887-91.
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Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity. PLoS Biol. 2006 Nov; 4(12):e416.