2',5'-Oligoadenylate Synthetase
"2',5'-Oligoadenylate Synthetase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the conversion of ATP into a series of (2'-5') linked oligoadenylates and pyrophosphate in the presence of double-stranded RNA. These oligonucleotides activate an endoribonuclease (RNase L) which cleaves single-stranded RNA. Interferons can act as inducers of these reactions.
| Descriptor ID |
D015088
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| MeSH Number(s) |
D08.811.913.696.445.625
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| Concept/Terms |
2',5'-Oligoadenylate Synthetase- 2',5'-Oligoadenylate Synthetase
- 2',5' Oligoadenylate Synthetase
- Synthetase, 2',5'-Oligoadenylate
- 2,5 Oligoadenylate Polymerase
- Oligoadenylate Polymerase, 2,5
- Polymerase, 2,5 Oligoadenylate
- 2',5'-Oligoadenylate Polymerase
- 2',5' Oligoadenylate Polymerase
- Polymerase, 2',5'-Oligoadenylate
- (2'-5')An Polymerase
- ATP-(2'-5')oligo(A)adenylyltransferase
- 2',5'-Oligo(A) Synthetase
- 2',5'-Oligo(A) Polymerase
- 2,5 Oligoadenylate Synthetase
- Oligoadenylate Synthetase, 2,5
- Synthetase, 2,5 Oligoadenylate
- 2-5A Synthetase
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Below are MeSH descriptors whose meaning is more general than "2',5'-Oligoadenylate Synthetase".
Below are MeSH descriptors whose meaning is more specific than "2',5'-Oligoadenylate Synthetase".
This graph shows the total number of publications written about "2',5'-Oligoadenylate Synthetase" by people in this website by year, and whether "2',5'-Oligoadenylate Synthetase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 2 | 0 | 2 |
| 2011 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "2',5'-Oligoadenylate Synthetase" by people in Profiles.
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Identification of a Sj?gren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons. PLoS Genet. 2017 Jun; 13(6):e1006820.
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Host genetic risk factors for West Nile virus infection and disease progression. PLoS One. 2011; 6(9):e24745.
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Single nucleotide polymorphisms in genes for 2'-5'-oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection. J Infect Dis. 2005 Nov 15; 192(10):1741-8.
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Mice deficient in oocyte-specific oligoadenylate synthetase-like protein OAS1D display reduced fertility. Mol Cell Biol. 2005 Jun; 25(11):4615-24.
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A phase I study of recombinant interferon-beta in patients with advanced malignant disease. Clin Cancer Res. 1999 Dec; 5(12):3990-8.
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Lymphocytic 2',5'-oligoadenylate synthetase activity increases prior to the appearance of neutralizing antibodies and immunoglobulin M and immunoglobulin G antibodies after primary and secondary immunization with yellow fever vaccine. Clin Diagn Lab Immunol. 1995 May; 2(3):302-6.
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Delivery of interferon to intracellular pathways by encapsulation of interferon into multilamellar liposomes is independent of the status of interferon receptors. Cytokine. 1994 Jul; 6(4):443-9.
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Immunological effects of treatment with sequential administration of recombinant interferon gamma and alpha in patients with metastatic renal cell carcinoma during a phase I trial. Cancer Res. 1992 Feb 15; 52(4):851-6.
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In vivo biological response to recombinant interferon-gamma during a phase I dose-response trial in patients with metastatic melanoma. J Clin Oncol. 1990 Jun; 8(6):1070-82.
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Growth regulation of A431 cells. Modulation of expression of transforming growth factor-alpha mRNA and 2',5'-oligoadenylate synthetase activity. J Biol Chem. 1990 Mar 15; 265(8):4578-82.