DNA (Cytosine-5-)-Methyltransferase 1
"DNA (Cytosine-5-)-Methyltransferase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DNA (cytosine-5-)-methyltransferase that contains a central CxxC type zinc finger motif. It binds poly(ADP)-ribose and its expression is regulated by POLY (ADP-RIBOSE) POLYMERASE-1. DNMT1 methylates CpG residues, with a preference for hemimethylated DNA, and associates with DNA replication sites in S PHASE to maintain the methylation pattern in the newly synthesized strand, which is essential for EPIGENETIC PROCESSES. It also associates with CHROMATIN during G2 PHASE and MITOSIS to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development; mutations in the DNMT1 gene are associated with HEREDITARY SENSORY NEUROPATHY TYPE 1 class E.
| Descriptor ID |
D000076123
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| MeSH Number(s) |
D08.811.913.555.500.350.100.500.500 D12.776.157.687.313 D12.776.660.720.313
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "DNA (Cytosine-5-)-Methyltransferase 1".
Below are MeSH descriptors whose meaning is more specific than "DNA (Cytosine-5-)-Methyltransferase 1".
This graph shows the total number of publications written about "DNA (Cytosine-5-)-Methyltransferase 1" by people in this website by year, and whether "DNA (Cytosine-5-)-Methyltransferase 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 3 | 3 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 4 | 4 |
| 2007 | 0 | 3 | 3 |
| 2008 | 0 | 5 | 5 |
| 2009 | 0 | 4 | 4 |
| 2010 | 0 | 2 | 2 |
| 2011 | 0 | 3 | 3 |
| 2012 | 0 | 4 | 4 |
| 2013 | 0 | 2 | 2 |
| 2014 | 0 | 2 | 2 |
| 2015 | 0 | 3 | 3 |
| 2016 | 2 | 0 | 2 |
| 2017 | 1 | 2 | 3 |
| 2018 | 1 | 1 | 2 |
| 2020 | 1 | 1 | 2 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "DNA (Cytosine-5-)-Methyltransferase 1" by people in Profiles.
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Mediating and maintaining methylation while minimizing mutation: Recent advances on mammalian DNA methyltransferases. Curr Opin Struct Biol. 2022 08; 75:102433.
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Epigenetic silencing of miR-342-3p in B cell lymphoma and its impact on autophagy. Clin Epigenetics. 2020 10 19; 12(1):150.
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UVB induces cutaneous squamous cell carcinoma progression by de novo ID4 methylation via methylation regulating enzymes. EBioMedicine. 2020 Jul; 57:102835.
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Epigenetic modification enhances the cytotoxicity of busulfan and4-hydroperoxycyclophosphamide in AML cells. Exp Hematol. 2018 11; 67:49-59.e1.
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Genetic variants in RORA and DNMT1 associated with cutaneous melanoma survival. Int J Cancer. 2018 06 01; 142(11):2303-2312.
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The Arginine Methyltransferase PRMT6 Regulates DNA Methylation and Contributes to Global DNA Hypomethylation in Cancer. Cell Rep. 2017 Dec 19; 21(12):3390-3397.
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Tobacco-Specific Carcinogens Induce Hypermethylation, DNA Adducts, and DNA Damage in Bladder Cancer. Cancer Prev Res (Phila). 2017 Oct; 10(10):588-597.
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DNA-Methyltransferase 1 Induces Dedifferentiation of Pancreatic Cancer Cells through Silencing of Kr?ppel-Like Factor 4 Expression. Clin Cancer Res. 2017 Sep 15; 23(18):5585-5597.
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RGS6 is an essential tumor suppressor that prevents bladder carcinogenesis by promoting p53 activation and DNMT1 downregulation. Oncotarget. 2016 Oct 25; 7(43):69159-69172.
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Essential Role of DNA Methyltransferase 1-mediated Transcription of Insulin-like Growth Factor 2 in Resistance to Histone Deacetylase Inhibitors. Clin Cancer Res. 2017 Mar 01; 23(5):1299-1311.