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DEAN EDWARDS

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
AddressOne Baylor Plaza
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pathology & Immunology
    DivisionPathology


    Collapse Research 
    Collapse research activities and funding
    R01CA263574     (GRIFFIN, PATRICK ROBERT)May 24, 2022 - Apr 30, 2027
    NIH
    Structural dynamics of progesterone receptor-coactivator complexes
    Role: Co-Principal Investigator
    T32GM008730     (PREKERIS, RYTIS)Jul 1, 1999 - Jun 30, 2020
    NIH
    Predoctoral Training Program in Molecular Biology
    Role: Co-Principal Investigator
    R01DK049030     (EDWARDS, DEAN P)Sep 30, 1994 - Jun 30, 2014
    NIH
    Steroid Antagonists and Resistance in Breast Cancer
    Role: Principal Investigator
    R21CA066207     (EDWARDS, DEAN P)Sep 30, 1994 - Sep 29, 1996
    NIH
    CANCER CENTER BREAST CANCER RESEARCH PROGRAM
    Role: Principal Investigator
    P20CA066207     (EDWARDS, DEAN P)Sep 30, 1994 - Sep 29, 1995
    NIH
    CANCER CENTER BREAST CANCER RESEARCH PROGRAM
    Role: Principal Investigator
    R01CA046938     (EDWARDS, DEAN P)Feb 1, 1988 - Feb 28, 2015
    NIH
    Progesterone Receptor Binding to Specific DNA Sequences
    Role: Principal Investigator
    R01CA041386     (EDWARDS, DEAN P)Mar 1, 1986 - Mar 31, 1993
    NIH
    IMMUNOLOGIC PROBES FOR STUDY OF PROGESTERONE RECEPTOR
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Edwards DN, Wang S, Kane K, Song W, Kim LC, Ngwa VM, Hwang Y, Ess K, Boothby MR, Chen J. Increased fatty acid delivery by tumor endothelium promotes metastatic outgrowth. JCI Insight. 2025 May 08; 10(9). PMID: 40198126.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Edwards DN, Wang S, Song W, Kim LC, Ngwa VM, Hwang Y, Ess KC, Boothby MR, Chen J. Regulation of fatty acid delivery to metastases by tumor endothelium. bioRxiv. 2024 Apr 03. PMID: 38617241; PMCID: PMC11014634.
      Citations:    
    3. Karno B, Edwards DN, Chen J. Metabolic control of cancer metastasis: role of amino acids at secondary organ sites. Oncogene. 2023 Nov; 42(47):3447-3456. PMID: 37848626; PMCID: PMC11323979.
      Citations:    
    4. Edwards DN. Amino Acid Metabolism in Bone Metastatic Disease. Curr Osteoporos Rep. 2023 08; 21(4):344-353. PMID: 37277592.
      Citations:    
    5. Ngwa VM, Edwards DN, Hwang Y, Karno B, Wang X, Yan C, Richmond A, Brantley-Sieders DM, Chen J. Loss of vascular endothelial glutaminase inhibits tumor growth and metastasis, and increases sensitivity to chemotherapy. Cancer Res Commun. 2022 07; 2(7):694-705. PMID: 36381236; PMCID: PMC9645801.
      Citations:    
    6. Edwards DN, Ngwa VM, Raybuck AL, Wang S, Hwang Y, Kim LC, Cho SH, Paik Y, Wang Q, Zhang S, Manning HC, Rathmell JC, Cook RS, Boothby MR, Chen J. Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer. J Clin Invest. 2021 02 15; 131(4). PMID: 33320840; PMCID: PMC7880417.
      Citations:    
    7. Song W, Kim LC, Han W, Hou Y, Edwards DN, Wang S, Blackwell TS, Cheng F, Brantley-Sieders DM, Chen J. Phosphorylation of PLC?1 by EphA2 Receptor Tyrosine Kinase Promotes Tumor Growth in Lung Cancer. Mol Cancer Res. 2020 11; 18(11):1735-1743. PMID: 32753469; PMCID: PMC7641970.
      Citations:    
    8. Ngwa VM, Edwards DN, Philip M, Chen J. Microenvironmental Metabolism Regulates Antitumor Immunity. Cancer Res. 2019 08 15; 79(16):4003-4008. PMID: 31362930; PMCID: PMC6697577.
      Citations:    
    9. Hwang Y, Kim LC, Song W, Edwards DN, Cook RS, Chen J. Disruption of the Scaffolding Function of mLST8 Selectively Inhibits mTORC2 Assembly and Function and Suppresses mTORC2-Dependent Tumor Growth In Vivo. Cancer Res. 2019 07 01; 79(13):3178-3184. PMID: 31085701; PMCID: PMC6606357.
      Citations:    
    10. Edwards DN, Ngwa VM, Wang S, Shiuan E, Brantley-Sieders DM, Kim LC, Reynolds AB, Chen J. The receptor tyrosine kinase EphA2 promotes glutamine metabolism in tumors by activating the transcriptional coactivators YAP and TAZ. Sci Signal. 2017 Dec 05; 10(508). PMID: 29208682; PMCID: PMC5819349.
      Citations:    
    11. Youngblood VM, Kim LC, Edwards DN, Hwang Y, Santapuram PR, Stirdivant SM, Lu P, Ye F, Brantley-Sieders DM, Chen J. The Ephrin-A1/EPHA2 Signaling Axis Regulates Glutamine Metabolism in HER2-Positive Breast Cancer. Cancer Res. 2016 04 01; 76(7):1825-36. PMID: 26833123; PMCID: PMC4873477.
      Citations:    
    12. Edwards DN, Machwe A, Chen L, Bohr VA, Orren DK. The DNA structure and sequence preferences of WRN underlie its function in telomeric recombination events. Nat Commun. 2015 Sep 30; 6:8331. PMID: 26420422; PMCID: PMC4589872.
      Citations:    
    13. Edwards DN, Orren DK, Machwe A. Strand exchange of telomeric DNA catalyzed by the Werner syndrome protein (WRN) is specifically stimulated by TRF2. Nucleic Acids Res. 2014 Jul; 42(12):7748-61. PMID: 24880691; PMCID: PMC4081078.
      Citations:    
    14. Edwards DN, Machwe A, Wang Z, Orren DK. Intramolecular telomeric G-quadruplexes dramatically inhibit DNA synthesis by replicative and translesion polymerases, revealing their potential to lead to genetic change. PLoS One. 2014; 9(1):e80664. PMID: 24454683; PMCID: PMC3891601.
      Citations:    
    15. Obr AE, Grimm SL, Bishop KA, Pike JW, Lydon JP, Edwards DP. Progesterone receptor and Stat5 signaling cross talk through RANKL in mammary epithelial cells. Mol Endocrinol. 2013 Nov; 27(11):1808-24. PMID: 24014651; PMCID: PMC3805851.
      Citations: 28     Fields:    Translation:AnimalsCells
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