Wiskott-Aldrich Syndrome Protein Family
"Wiskott-Aldrich Syndrome Protein Family" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of microfilament proteins whose name derives from the fact that mutations in members of this protein family have been associated with WISKOTT-ALDRICH SYNDROME. They are involved in ACTIN polymerization and contain a polyproline-rich region that binds to PROFILIN, and a verprolin homology domain that binds G-ACTIN.
Descriptor ID |
D051300
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MeSH Number(s) |
D05.750.078.730.912 D12.776.220.525.912
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Wiskott-Aldrich Syndrome Protein Family".
Below are MeSH descriptors whose meaning is more specific than "Wiskott-Aldrich Syndrome Protein Family".
This graph shows the total number of publications written about "Wiskott-Aldrich Syndrome Protein Family" by people in this website by year, and whether "Wiskott-Aldrich Syndrome Protein Family" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1999 | 0 | 1 | 1 |
2006 | 1 | 0 | 1 |
2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Wiskott-Aldrich Syndrome Protein Family" by people in Profiles.
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HEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory disease. Science. 2020 07 10; 369(6500):202-207.
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Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson's disease. Proc Natl Acad Sci U S A. 2018 05 29; 115(22):E5164-E5173.
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Genomic analysis of the chromosome 15q11-q13 Prader-Willi syndrome region and characterization of transcripts for GOLGA8E and WHCD1L1 from the proximal breakpoint region. BMC Genomics. 2008 Jan 28; 9:50.
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WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination. J Neurosci. 2006 May 24; 26(21):5849-59.
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Phosphorylation of WAVE downstream of mitogen-activated protein kinase signaling. J Biol Chem. 1999 Sep 24; 274(39):27605-9.