Wiskott-Aldrich Syndrome Protein
"Wiskott-Aldrich Syndrome Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
WASP protein is mutated in WISKOTT-ALDRICH SYNDROME and is expressed primarily in hematopoietic cells. It is the founding member of the WASP protein family and interacts with CDC42 PROTEIN to help regulate ACTIN polymerization.
| Descriptor ID |
D051316
|
| MeSH Number(s) |
D05.750.078.730.912.500 D12.776.220.525.912.500
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Wiskott-Aldrich Syndrome Protein".
Below are MeSH descriptors whose meaning is more specific than "Wiskott-Aldrich Syndrome Protein".
This graph shows the total number of publications written about "Wiskott-Aldrich Syndrome Protein" by people in this website by year, and whether "Wiskott-Aldrich Syndrome Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Wiskott-Aldrich Syndrome Protein" by people in Profiles.
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Outcomes of hematopoietic stem cell gene therapy for Wiskott-Aldrich syndrome. Blood. 2023 10 12; 142(15):1281-1296.
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WASp controls oriented migration of endothelial cells to achieve functional vascular patterning. Development. 2022 02 01; 149(3).
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Excellent outcomes following hematopoietic cell transplantation for Wiskott-Aldrich syndrome: a PIDTC report. Blood. 2020 06 04; 135(23):2094-2105.
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IL-2 in the tumor microenvironment is necessary for Wiskott-Aldrich syndrome protein deficient NK cells to respond to tumors in vivo. Sci Rep. 2016 08 01; 6:30636.
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Tricornered Kinase Regulates Synapse Development by Regulating the Levels of Wiskott-Aldrich Syndrome Protein. PLoS One. 2015; 10(9):e0138188.
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The Arp2/3 complex and WASp are required for apical trafficking of Delta into microvilli during cell fate specification of sensory organ precursors. Nat Cell Biol. 2009 Jul; 11(7):815-24.
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Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells. Proc Natl Acad Sci U S A. 2007 Jan 30; 104(5):1593-8.
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The last 80 years in primary immunodeficiency: how far have we come, how far need we go? J Allergy Clin Immunol. 2006 Apr; 117(4):748-52.
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Manifestations and linkage analysis in X-linked autoimmunity-immunodeficiency syndrome. Am J Med Genet. 2000 Feb 28; 90(5):390-7.
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Novel mutations in the Wiskott-Aldrich syndrome protein gene and their effects on transcriptional, translational, and clinical phenotypes. Hum Mutat. 1999; 14(1):54-66.