WW Domain-Containing Oxidoreductase
"WW Domain-Containing Oxidoreductase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A short chain oxidoreductase that contains two N-terminal WW DOMAINS and functions as a tumor suppressor and in APOPTOSIS. It is also required for bone development.
| Descriptor ID |
D000074584
|
| MeSH Number(s) |
D08.811.682.047.820.900.500 D12.776.624.776.980
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "WW Domain-Containing Oxidoreductase".
Below are MeSH descriptors whose meaning is more specific than "WW Domain-Containing Oxidoreductase".
This graph shows the total number of publications written about "WW Domain-Containing Oxidoreductase" by people in this website by year, and whether "WW Domain-Containing Oxidoreductase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 4 | 4 |
| 2006 | 0 | 3 | 3 |
| 2007 | 0 | 4 | 4 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 2 | 2 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 2 | 2 |
| 2014 | 0 | 2 | 2 |
| 2016 | 0 | 1 | 1 |
| 2018 | 2 | 0 | 2 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 2 | 1 | 3 |
| 2022 | 1 | 1 | 2 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "WW Domain-Containing Oxidoreductase" by people in Profiles.
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WWOX P47T partial loss-of-function mutation induces epilepsy, progressive neuroinflammation, and cerebellar degeneration in mice phenocopying human SCAR12. Prog Neurobiol. 2023 04; 223:102425.
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Expansion of the clinical and molecular spectrum of WWOX-related epileptic encephalopathy. Am J Med Genet A. 2023 03; 191(3):776-785.
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Wwox Binding to the Murine Brca1-BRCT Domain Regulates Timing of Brip1 and CtIP Phospho-Protein Interactions with This Domain at DNA Double-Strand Breaks, and Repair Pathway Choice. Int J Mol Sci. 2022 Mar 28; 23(7).
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Interaction of Wwox with Brca1 and associated complex proteins prevents premature resection at double-strand breaks and aberrant homologous recombination. DNA Repair (Amst). 2022 02; 110:103264.
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RHBDD2-WWOX protein interaction during proliferative and differentiated stages in normal and breast cancer cells. Oncol Rep. 2021 Aug; 46(2).
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Cigarette Smoke and Nicotine-Containing Electronic-Cigarette Vapor Downregulate Lung WWOX Expression, Which Is Associated with Increased Severity of Murine Acute Respiratory Distress Syndrome. Am J Respir Cell Mol Biol. 2021 01; 64(1):89-99.
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WWOX Loss of Function in Neurodevelopmental and Neurodegenerative Disorders. Int J Mol Sci. 2020 Nov 24; 21(23).
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Exome Sequencing of Two Siblings with Sporadic Autism Spectrum Disorder and Severe Speech Sound Disorder Suggests Pleiotropic and Complex Effects. Behav Genet. 2019 07; 49(4):399-414.
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Novel WWOX deleterious variants cause early infantile epileptic encephalopathy, severe developmental delay and dysmorphism among Yemenite Jews. Eur J Paediatr Neurol. 2019 May; 23(3):418-426.
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Wwox deletion leads to reduced GABA-ergic inhibitory interneuron numbers and activation of microglia and astrocytes in mouse hippocampus. Neurobiol Dis. 2019 01; 121:163-176.