WW Domain-Containing Oxidoreductase
"WW Domain-Containing Oxidoreductase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A short chain oxidoreductase that contains two N-terminal WW DOMAINS and functions as a tumor suppressor and in APOPTOSIS. It is also required for bone development.
| Descriptor ID |
D000074584
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| MeSH Number(s) |
D08.811.682.047.820.900.500 D12.776.624.776.980
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| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "WW Domain-Containing Oxidoreductase".
Below are MeSH descriptors whose meaning is more specific than "WW Domain-Containing Oxidoreductase".
This graph shows the total number of publications written about "WW Domain-Containing Oxidoreductase" by people in this website by year, and whether "WW Domain-Containing Oxidoreductase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "WW Domain-Containing Oxidoreductase" by people in Profiles.
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WWOX P47T partial loss-of-function mutation induces epilepsy, progressive neuroinflammation, and cerebellar degeneration in mice phenocopying human SCAR12. Prog Neurobiol. 2023 04; 223:102425.
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Expansion of the clinical and molecular spectrum of WWOX-related epileptic encephalopathy. Am J Med Genet A. 2023 03; 191(3):776-785.
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The tumour suppressor gene WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation. Brain. 2014 Feb; 137(Pt 2):411-9.
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The cancer gene WWOX behaves as an inhibitor of SMAD3 transcriptional activity via direct binding. BMC Cancer. 2013 Dec 11; 13:593.
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Conditional Wwox deletion in mouse mammary gland by means of two Cre recombinase approaches. PLoS One. 2012; 7(5):e36618.
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Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor gene. PLoS One. 2009 Nov 10; 4(11):e7775.
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Low levels of WWOX protein immunoexpression correlate with tumour grade and a less favourable outcome in patients with urinary bladder tumours. Histopathology. 2008 Jun; 52(7):831-9.
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Molecular alterations in the tumor suppressor gene WWOX in oral leukoplakias. Oral Oncol. 2008 Aug; 44(8):753-8.
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WWOX hypomorphic mice display a higher incidence of B-cell lymphomas and develop testicular atrophy. Genes Chromosomes Cancer. 2007 Dec; 46(12):1129-36.
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Association between decreased WWOX protein expression and thyroid cancer development. Thyroid. 2007 Nov; 17(11):1055-9.