Amyloid Precursor Protein Secretases
"Amyloid Precursor Protein Secretases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Endopeptidases that are specific for AMYLOID PROTEIN PRECURSOR. Three secretase subtypes referred to as alpha, beta, and gamma have been identified based upon the region of amyloid protein precursor they cleave.
| Descriptor ID |
D053829
|
| MeSH Number(s) |
D08.811.277.656.300.032
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Amyloid Precursor Protein Secretases".
Below are MeSH descriptors whose meaning is more specific than "Amyloid Precursor Protein Secretases".
This graph shows the total number of publications written about "Amyloid Precursor Protein Secretases" by people in this website by year, and whether "Amyloid Precursor Protein Secretases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 2 | 2 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 5 | 5 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 2 | 2 |
| 2008 | 3 | 0 | 3 |
| 2009 | 1 | 2 | 3 |
| 2010 | 1 | 0 | 1 |
| 2011 | 2 | 2 | 4 |
| 2012 | 1 | 2 | 3 |
| 2013 | 2 | 4 | 6 |
| 2014 | 5 | 1 | 6 |
| 2015 | 1 | 2 | 3 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
| 2026 | 1 | 0 | 1 |
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Below are the most recent publications written about "Amyloid Precursor Protein Secretases" by people in Profiles.
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Predicting Sepsis in Heart Failure Patients Supported by Left Ventricular Assist Devices: The Role of VE-Cadherin and ADAM10. Int J Mol Sci. 2026 Jan 06; 27(2).
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Targeting PSEN1 by lnc-CYP3A43-2/miR-29b-2-5p to Reduce ? Amyloid Plaque Formation and Improve Cognition Function. Int J Mol Sci. 2022 Sep 11; 23(18).
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Plasma amyloid ? levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants. Alzheimers Dement. 2021 10; 17(10):1663-1674.
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miR-18a Inhibits BMP4 and HIF-1a Normalizing Brain Arteriovenous Malformations. Circ Res. 2020 10 09; 127(9):e210-e231.
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Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription. Cell. 2019 08 22; 178(5):1159-1175.e17.
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MicroRNA-197 controls ADAM10 expression to mediate MeCP2's role in the differentiation of neuronal progenitors. Cell Death Differ. 2019 10; 26(10):1863-1879.
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Functional Variants in Notch Pathway Genes NCOR2, NCSTN, and MAML2 Predict Survival of Patients with Cutaneous Melanoma. Cancer Epidemiol Biomarkers Prev. 2015 Jul; 24(7):1101-10.
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Phase I trial of weekly MK-0752 in children with refractory central nervous system malignancies: a pediatric brain tumor consortium study. Childs Nerv Syst. 2015 Aug; 31(8):1283-9.
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Posttraumatic stress disorder-like induction elevates ?-amyloid levels, which directly activates corticotropin-releasing factor neurons to exacerbate stress responses. J Neurosci. 2015 Feb 11; 35(6):2612-23.
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The transcriptional corepressor MTGR1 regulates intestinal secretory lineage allocation. FASEB J. 2015 Mar; 29(3):786-95.