Aspartic Acid Endopeptidases
"Aspartic Acid Endopeptidases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A sub-subclass of endopeptidases that depend on an ASPARTIC ACID residue for their activity.
| Descriptor ID |
D016282
|
| MeSH Number(s) |
D08.811.277.656.074.500 D08.811.277.656.300.048
|
| Concept/Terms |
Aspartic Acid Endopeptidases- Aspartic Acid Endopeptidases
- Acid Endopeptidases, Aspartic
- Endopeptidases, Aspartic Acid
- Aspartyl Endopeptidases
- Endopeptidases, Aspartyl
- Aspartic Endopeptidases
|
Below are MeSH descriptors whose meaning is more general than "Aspartic Acid Endopeptidases".
Below are MeSH descriptors whose meaning is more specific than "Aspartic Acid Endopeptidases".
This graph shows the total number of publications written about "Aspartic Acid Endopeptidases" by people in this website by year, and whether "Aspartic Acid Endopeptidases" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 1999 | 1 | 0 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 2 | 2 |
| 2002 | 0 | 1 | 1 |
| 2003 | 1 | 5 | 6 |
| 2004 | 0 | 3 | 3 |
| 2005 | 2 | 1 | 3 |
| 2006 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2009 | 0 | 2 | 2 |
| 2015 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Aspartic Acid Endopeptidases" by people in Profiles.
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Plasma amyloid ? levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants. Alzheimers Dement. 2021 10; 17(10):1663-1674.
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A novel blood-feeding detoxification pathway in Nippostrongylus brasiliensis L3 reveals a potential checkpoint for arresting hookworm development. PLoS Pathog. 2018 03; 14(3):e1006931.
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Association of a Novel Mutation in the Plasmodium falciparum Chloroquine Resistance Transporter With Decreased Piperaquine Sensitivity. J Infect Dis. 2017 08 15; 216(4):468-476.
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Expression, purification, and characterization of the Necator americanus aspartic protease-1 (Na-APR-1 (M74)) antigen, a component of the bivalent human hookworm vaccine. Hum Vaccin Immunother. 2015; 11(6):1474-88.
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Semiautomated laser capture microdissection of lung adenocarcinoma cytology samples. Acta Cytol. 2012; 56(6):622-31.
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Structure- and property-based design of aminooxazoline xanthenes as selective, orally efficacious, and CNS penetrable BACE inhibitors for the treatment of Alzheimer's disease. J Med Chem. 2012 Nov 08; 55(21):9156-69.
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Design and synthesis of potent, orally efficacious hydroxyethylamine derived ?-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors. J Med Chem. 2012 Nov 08; 55(21):9025-44.
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Design and preparation of a potent series of hydroxyethylamine containing ?-secretase inhibitors that demonstrate robust reduction of central ?-amyloid. J Med Chem. 2012 Nov 08; 55(21):9009-24.
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Chronic nicotine restores normal A? levels and prevents short-term memory and E-LTP impairment in A? rat model of Alzheimer's disease. Neurobiol Aging. 2011 May; 32(5):834-44.
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Proteolytic degradation of hemoglobin in the intestine of the human hookworm Necator americanus. J Infect Dis. 2009 Mar 15; 199(6):904-12.