"Cathepsin D" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An intracellular proteinase found in a variety of tissue. It has specificity similar to but narrower than that of pepsin A. The enzyme is involved in catabolism of cartilage and connective tissue. EC 3.4.23.5. (Formerly EC 3.4.4.23).
| Descriptor ID |
D002402
|
| MeSH Number(s) |
D08.811.277.656.074.500.180 D08.811.277.656.224.187 D08.811.277.656.300.048.180
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Cathepsin D".
Below are MeSH descriptors whose meaning is more specific than "Cathepsin D".
This graph shows the total number of publications written about "Cathepsin D" by people in this website by year, and whether "Cathepsin D" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 2002 | 1 | 1 | 2 |
| 2004 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2017 | 1 | 1 | 2 |
| 2020 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Cathepsin D" by people in Profiles.
-
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective. Autophagy. 2021 06; 17(6):1330-1348.
-
Excessive burden of lysosomal storage disorder gene variants in Parkinson's disease. Brain. 2017 12 01; 140(12):3191-3203.
-
Dual Detection of Nucleolytic and Proteolytic Markers of Lysosomal Cell Death: DNase II-Type Breaks and Cathepsin D. Methods Mol Biol. 2017; 1554:229-236.
-
The senescence-associated secretory phenotype promotes benign prostatic hyperplasia. Am J Pathol. 2014 Mar; 184(3):721-31.
-
Deletion of the olfactomedin 4 gene is associated with progression of human prostate cancer. Am J Pathol. 2013 Oct; 183(4):1329-38.
-
Identification of a novel estrogen receptor-alpha variant and its upstream splicing regulator. Mol Endocrinol. 2010 May; 24(5):914-22.
-
Basement membrane derived fibulin-1 and fibulin-5 function as angiogenesis inhibitors and suppress tumor growth. Exp Biol Med (Maywood). 2008 Feb; 233(2):155-62.
-
American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer. J Clin Oncol. 2007 Nov 20; 25(33):5287-312.
-
Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway. J Cell Biol. 2004 Sep 27; 166(7):1041-54.
-
Identification of a transferable two-amino-acid motif (GT) present in the C-terminal tail of the human lutropin receptor that redirects internalized G protein-coupled receptors from a degradation to a recycling pathway. Mol Endocrinol. 2003 Mar; 17(3):411-22.