"Cathepsin L" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ubiquitously-expressed cysteine protease that plays an enzymatic role in POST-TRANSLATIONAL PROTEIN PROCESSING of proteins within SECRETORY GRANULES.
| Descriptor ID |
D056668
|
| MeSH Number(s) |
D08.811.277.656.224.407 D08.811.277.656.262.500.157 D08.811.277.656.300.200.157
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Cathepsin L".
Below are MeSH descriptors whose meaning is more specific than "Cathepsin L".
This graph shows the total number of publications written about "Cathepsin L" by people in this website by year, and whether "Cathepsin L" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 2 | 2 |
| 2003 | 0 | 4 | 4 |
| 2012 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cathepsin L" by people in Profiles.
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Protecting glomerulus: role of angiotensin-II type 2 receptor. Clin Sci (Lond). 2022 10 28; 136(20):1467-1470.
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Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics. Nat Med. 2021 03; 27(3):546-559.
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Discovery of covalent enzyme inhibitors using virtual docking of covalent fragments. Bioorg Med Chem Lett. 2019 01 01; 29(1):36-39.
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Small-molecule inhibitors of cathepsin L incorporating functionalized ring-fused molecular frameworks. Bioorg Med Chem Lett. 2013 May 01; 23(9):2801-7.
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Protective role of cathepsin L in mouse skin carcinogenesis. Mol Carcinog. 2012 Apr; 51(4):352-61.
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Inhibition of tumorigenicity and metastasis of human melanoma cells by anti-cathepsin L single chain variable fragment. Cancer Res. 2004 Jan 01; 64(1):146-51.
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Induction of cytotoxic T-lymphocyte antigen-2beta, a cysteine protease inhibitor in decidua: a potential regulator of embryo implantation. J Biol Chem. 2004 Mar 12; 279(11):10357-63.
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Cathepsin L gene expression and promoter activation in rodent granulosa cells. Endocrinology. 2004 Feb; 145(2):582-91.
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Cathepsin B but not cathepsins L or S contributes to the pathogenesis of Unverricht-Lundborg progressive myoclonus epilepsy (EPM1). J Neurobiol. 2003 Sep 15; 56(4):315-27.
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Inhibition of the cysteine proteinases cathepsins K and L by the serpin headpin (SERPINB13): a kinetic analysis. Arch Biochem Biophys. 2003 Jan 15; 409(2):367-74.