Nedd4 Ubiquitin Protein Ligases
"Nedd4 Ubiquitin Protein Ligases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
E3 ubiquitin ligases that consist of four WW DOMAINS. They accept UBIQUITIN from E2 UBIQUITIN-CONJUGATING ENZYME as a thioester via their C-terminal HECT domains and transfer it specifically to the 63rd LYSINE residue (Lys-63) of target proteins. NEDD4 targets include many proteins and receptors with important functions for cell growth and homeostasis such as VEGFR-2; FGFR1 TYROSINE KINASE; and ERBB-4 RECEPTOR. They play a critical role in the internalization of these receptors, their degradation by LYSOSOMES, and also function as part of the ESCRT complex in VIRUS RELEASE.
| Descriptor ID |
D000075702
|
| MeSH Number(s) |
D05.500.199.500 D08.811.464.938.750.257 D12.776.543.990.493.500
|
| Concept/Terms |
Nedd4 Ubiquitin Protein Ligases- Nedd4 Ubiquitin Protein Ligases
- Nedd4 Proteins
- Neuronal Precursor Cell-Expressed Developmentally Down-Regulated 4 Ligase
- Neuronal Precursor Cell Expressed Developmentally Down Regulated 4 Ligase
|
Below are MeSH descriptors whose meaning is more general than "Nedd4 Ubiquitin Protein Ligases".
Below are MeSH descriptors whose meaning is more specific than "Nedd4 Ubiquitin Protein Ligases".
This graph shows the total number of publications written about "Nedd4 Ubiquitin Protein Ligases" by people in this website by year, and whether "Nedd4 Ubiquitin Protein Ligases" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Nedd4 Ubiquitin Protein Ligases" by people in Profiles.
-
FAT10 protects against ischemia-induced ventricular arrhythmia by decreasing Nedd4-2/Nav1.5 complex formation. Cell Death Dis. 2021 01 05; 12(1):25.
-
The Daam2-VHL-Nedd4 axis governs developmental and regenerative oligodendrocyte differentiation. Genes Dev. 2020 09 01; 34(17-18):1177-1189.
-
Deletion of ubiquitin ligase Nedd4l exacerbates ischemic brain damage. J Cereb Blood Flow Metab. 2021 05; 41(5):1058-1066.
-
Estrogen receptor ?, a regulator of androgen receptor signaling in the mouse ventral prostate. Proc Natl Acad Sci U S A. 2017 05 09; 114(19):E3816-E3822.
-
H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis. Nat Commun. 2017 03 16; 8:14799.
-
Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress. PLoS Pathog. 2017 01; 13(1):e1006132.
-
Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4-NDRG1 Axis. Cancer Res. 2017 01 01; 77(1):86-99.
-
SGK3 Sensitivity of Voltage Gated K+ Channel Kv1.5 (KCNA5). Cell Physiol Biochem. 2016; 38(1):359-67.
-
A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism. J Am Chem Soc. 2015 Oct 07; 137(39):12442-5.
-
Abnormal splicing of NEDD4 in myotonic dystrophy type 2: possible link to statin adverse reactions. Am J Pathol. 2014 Aug; 184(8):2322-32.