Histone-Lysine N-Methyltransferase
"Histone-Lysine N-Methyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the methylation of the epsilon-amino group of lysine residues in proteins to yield epsilon mono-, di-, and trimethyllysine. EC 2.1.1.43.
| Descriptor ID |
D011495
|
| MeSH Number(s) |
D08.811.913.555.500.800.400
|
| Concept/Terms |
Histone-Lysine N-Methyltransferase- Histone-Lysine N-Methyltransferase
- Histone Lysine N Methyltransferase
- N-Methyltransferase, Histone-Lysine
- Protein Methylase III
- Histone-Lysine Methyltransferase
- Histone Lysine Methyltransferase
- Methyltransferase, Histone-Lysine
- Protein Lysine Methyltransferase
- Methyltransferase, Protein Lysine
- Protein Methyltransferase III
|
Below are MeSH descriptors whose meaning is more general than "Histone-Lysine N-Methyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Histone-Lysine N-Methyltransferase".
This graph shows the total number of publications written about "Histone-Lysine N-Methyltransferase" by people in this website by year, and whether "Histone-Lysine N-Methyltransferase" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 4 | 4 |
| 2006 | 1 | 1 | 2 |
| 2007 | 0 | 2 | 2 |
| 2008 | 2 | 1 | 3 |
| 2009 | 0 | 2 | 2 |
| 2010 | 0 | 4 | 4 |
| 2011 | 1 | 3 | 4 |
| 2012 | 2 | 5 | 7 |
| 2013 | 0 | 7 | 7 |
| 2014 | 4 | 4 | 8 |
| 2015 | 0 | 4 | 4 |
| 2016 | 3 | 5 | 8 |
| 2017 | 1 | 1 | 2 |
| 2018 | 5 | 1 | 6 |
| 2019 | 2 | 1 | 3 |
| 2020 | 6 | 3 | 9 |
| 2021 | 5 | 1 | 6 |
| 2022 | 0 | 2 | 2 |
| 2023 | 1 | 1 | 2 |
| 2024 | 6 | 2 | 8 |
| 2025 | 2 | 3 | 5 |
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Below are the most recent publications written about "Histone-Lysine N-Methyltransferase" by people in Profiles.
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Disparate leukemia mutations converge on nuclear phase-separated condensates. Cell. 2025 Dec 11; 188(25):7118-7136.e21.
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KMT2D temporally activates neuronal transcriptional factor genes to mediate cerebellar granule cell differentiation. Sci Adv. 2025 Sep 26; 11(39):eadu7174.
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Lysosomes signal through the epigenome to regulate longevity across generations. Science. 2025 Sep 25; 389(6767):1353-1360.
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Synthesis, Structure-Activity Relationships, and Antitumor Activities of Quinoxiline-Containing Inhibitors of the Protein-Protein Interactions between Transcription Coactivator AF9/ENL and DOT1L/AF4. J Med Chem. 2025 Sep 25; 68(18):19396-19414.
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Guanine nucleotide biosynthesis blockade impairs MLL complex formation and sensitizes leukemias to menin inhibition. Nat Commun. 2025 Mar 18; 16(1):2641.
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Stem cell activity-coupled suppression of endogenous retrovirus governs adult tissue regeneration. Cell. 2024 Dec 26; 187(26):7414-7432.e26.
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MLL oncoprotein levels influence leukemia lineage identities. Nat Commun. 2024 10 29; 15(1):9341.
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Selective inhibition of HDAC class IIA as therapeutic intervention for KMT2A-rearranged acute lymphoblastic leukemia. Commun Biol. 2024 10 04; 7(1):1257.
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Perturbing TET2 condensation promotes aberrant genome-wide DNA methylation and curtails leukaemia cell growth. Nat Cell Biol. 2024 Dec; 26(12):2154-2167.
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Identification of single-cell blasts in pediatric acute myeloid leukemia using an autoencoder. Life Sci Alliance. 2024 11; 7(11).