Polycomb Repressive Complex 2
"Polycomb Repressive Complex 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multisubunit polycomb protein complex that catalyzes the METHYLATION of chromosomal HISTONE H3. It works in conjunction with POLYCOMB REPRESSIVE COMPLEX 1 to effect EPIGENETIC REPRESSION.
| Descriptor ID |
D063151
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| MeSH Number(s) |
D05.500.781.750 D08.811.913.555.500.800.400.500 D12.776.660.235.600.200 D12.776.664.235.800.200 D12.776.930.780.890.200
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Polycomb Repressive Complex 2".
Below are MeSH descriptors whose meaning is more specific than "Polycomb Repressive Complex 2".
This graph shows the total number of publications written about "Polycomb Repressive Complex 2" by people in this website by year, and whether "Polycomb Repressive Complex 2" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 1 | 2 |
| 2014 | 1 | 3 | 4 |
| 2015 | 2 | 0 | 2 |
| 2016 | 2 | 0 | 2 |
| 2018 | 1 | 0 | 1 |
| 2019 | 0 | 3 | 3 |
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 2 | 2 |
| 2026 | 1 | 2 | 3 |
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Below are the most recent publications written about "Polycomb Repressive Complex 2" by people in Profiles.
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H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programs. Nat Genet. 2026 Jun; 58(6):1368-1382.
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JMJD3 as an epigenetic regulator in development and disease. Int J Biochem Cell Biol. 2015 Oct; 67:148-57.
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An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth. Nat Commun. 2014 Nov 05; 5:5425.
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EZH2 expression correlates with locoregional recurrence after radiation in inflammatory breast cancer. J Exp Clin Cancer Res. 2014 Jul 23; 33:58.
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VEGF/VEGFR-2 upregulates EZH2 expression in lung adenocarcinoma cells and EZH2 depletion enhances the response to platinum-based and VEGFR-2-targeted therapy. Clin Cancer Res. 2014 Jul 15; 20(14):3849-61.
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Metronomic docetaxel in PRINT nanoparticles and EZH2 silencing have synergistic antitumor effect in ovarian cancer. Mol Cancer Ther. 2014 Jul; 13(7):1750-7.
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Epigenomic alterations define lethal CIMP-positive ependymomas of infancy. Nature. 2014 Feb 27; 506(7489):445-50.
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Effect of estrogen receptor a binding on functional DNA methylation in breast cancer. Epigenetics. 2014 Apr; 9(4):523-32.
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Long non-coding RNA HOTAIR in carcinogenesis and metastasis. Acta Biochim Biophys Sin (Shanghai). 2014 Jan; 46(1):1-5.
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Cutting edge: Smad2 and Smad4 regulate TGF-?-mediated Il9 gene expression via EZH2 displacement. J Immunol. 2013 Nov 15; 191(10):4908-12.