"Phosphodiesterase I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phosphoric diester hydrolase that removes 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated OLIGONUCLEOTIDES. It has low activity towards POLYNUCLEOTIDES and the presence of 3'-phosphate terminus on the substrate may inhibit hydrolysis.
| Descriptor ID |
D043264
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| MeSH Number(s) |
D08.811.277.352.640.430
|
| Concept/Terms |
Phosphodiesterase I- Phosphodiesterase I
- Orthophosphoric Diester Phosphohydrolase
- Diester Phosphohydrolase, Orthophosphoric
- Phosphohydrolase, Orthophosphoric Diester
- Alkaline Phosphodiesterase I
- Phosphodiesterase I, Alkaline
- 5'-Nucleotidephosphodiesterase
- 5' Nucleotidephosphodiesterase
- Alkaline Phosphodiesterase
- Phosphodiesterase, Alkaline
- Oligonucleate 5'-Nucleotidohydrolase
- Oligonucleate 5' Nucleotidohydrolase
- 5'-Exonuclease
- 5' Exonuclease
|
Below are MeSH descriptors whose meaning is more general than "Phosphodiesterase I".
Below are MeSH descriptors whose meaning is more specific than "Phosphodiesterase I".
This graph shows the total number of publications written about "Phosphodiesterase I" by people in this website by year, and whether "Phosphodiesterase I" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2009 | 3 | 0 | 3 |
| 2010 | 0 | 3 | 3 |
| 2011 | 1 | 1 | 2 |
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Below are the most recent publications written about "Phosphodiesterase I" by people in Profiles.
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Benzyl and naphthalene methylphosphonic acid inhibitors of autotaxin with anti-invasive and anti-metastatic activity. ChemMedChem. 2011 May 02; 6(5):922-35.
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Location, location, location: a crystal-clear view of autotaxin saturating LPA receptors. Nat Struct Mol Biol. 2011 Feb; 18(2):117-8.
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Synthesis and pharmacological evaluation of the stereoisomers of 3-carba cyclic-phosphatidic acid. Bioorg Med Chem Lett. 2010 Dec 15; 20(24):7525-8.
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Targeting melanoma growth and viability reveals dualistic functionality of the phosphonothionate analogue of carba cyclic phosphatidic acid. Mol Cancer. 2010 Jun 09; 9:140.
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Lysophosphatidic acid production and action: critical new players in breast cancer initiation and progression. Br J Cancer. 2010 Mar 16; 102(6):941-6.
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ATX-LPA receptor axis in inflammation and cancer. Cell Cycle. 2009 Nov 15; 8(22):3695-701.
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Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases. Cancer Cell. 2009 Jun 02; 15(6):539-50.
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Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis. J Biol Chem. 2009 Mar 13; 284(11):7385-94.
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Premature cell cycle entry induced by hepatitis B virus regulatory HBx protein during compensatory liver regeneration. Cancer Res. 2008 Dec 15; 68(24):10341-8.
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Autotaxin and lysophosphatidic acid stimulate intestinal cell motility by redistribution of the actin modifying protein villin to the developing lamellipodia. Exp Cell Res. 2008 Feb 01; 314(3):530-42.