"Focal Adhesion Kinase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A non-receptor protein-tyrosine kinase that is expressed primarily in the BRAIN; OSTEOBLASTS; and LYMPHOID CELLS. In the CENTRAL NERVOUS SYSTEM focal adhesion kinase 2 modulates ION CHANNEL function and MITOGEN-ACTIVATED PROTEIN KINASES activity.
| Descriptor ID |
D051418
|
| MeSH Number(s) |
D08.811.913.696.620.682.725.049.750 D23.050.301.500.600.350 D23.050.705.552.600.350
|
| Concept/Terms |
Focal Adhesion Kinase 2- Focal Adhesion Kinase 2
- RAFTK Protein
- Cell Adhesion Kinase Beta
- Proline-Rich Tyrosine Kinase 2
- Proline Rich Tyrosine Kinase 2
- Related Adhesion Focal Tyrosine Kinase
- CADTK Protein
- Focal Adhesion Kinase Autokinase
- FAK Autokinase
- Calcium-Dependent Protein Tyrosine Kinase
- Calcium Dependent Protein Tyrosine Kinase
- PYK2 Protein Tyrosine Kinase
- Protein Tyrosine Kinase PYK2
|
Below are MeSH descriptors whose meaning is more general than "Focal Adhesion Kinase 2".
Below are MeSH descriptors whose meaning is more specific than "Focal Adhesion Kinase 2".
This graph shows the total number of publications written about "Focal Adhesion Kinase 2" by people in this website by year, and whether "Focal Adhesion Kinase 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2022 | 1 | 0 | 1 |
| 2023 | 1 | 0 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Focal Adhesion Kinase 2" by people in Profiles.
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Post-ischemic ubiquitination at the postsynaptic density reversibly influences the activity of ischemia-relevant kinases. Commun Biol. 2024 03 13; 7(1):321.
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Integrin signaling is critical for myeloid-mediated support of T-cell acute lymphoblastic leukemia. Nat Commun. 2023 10 07; 14(1):6270.
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Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling. Sci Signal. 2022 05 10; 15(733):eabh3066.
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Calcium/calmodulin-dependent protein kinase kinase 2 regulates macrophage-mediated inflammatory responses. J Biol Chem. 2012 Mar 30; 287(14):11579-91.
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PKC-alpha and TAK-1 are intermediates in the activation of c-Jun NH2-terminal kinase by hypoxia-reoxygenation. Am J Physiol Heart Circ Physiol. 2007 Apr; 292(4):H1675-84.
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Role of the Pyk2-MAP kinase-cPLA2 signaling pathway in shear-dependent platelet aggregation. Ann Biomed Eng. 2004 Sep; 32(9):1193-201.
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Mitochondrial signals initiate the activation of c-Jun N-terminal kinase (JNK) by hypoxia-reoxygenation. FASEB J. 2004 Jul; 18(10):1060-70.
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Paxillin binding to the alpha 4 integrin subunit stimulates LFA-1 (integrin alpha L beta 2)-dependent T cell migration by augmenting the activation of focal adhesion kinase/proline-rich tyrosine kinase-2. J Immunol. 2003 Jun 15; 170(12):5912-8.
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SETA/CIN85/Ruk and its binding partner AIP1 associate with diverse cytoskeletal elements, including FAKs, and modulate cell adhesion. J Cell Sci. 2003 07 15; 116(Pt 14):2845-55.
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Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo. Proc Natl Acad Sci U S A. 2001 Aug 28; 98(18):10031-3.