"Caspase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Activation of this enzyme can occur via the interaction of its caspase recruitment domain with CARD SIGNALING ADAPTOR PROTEINS. Caspase 2 plays a role in APOPTOSIS by cleaving and activating effector pro-caspases. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.
Descriptor ID |
D053143
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MeSH Number(s) |
D08.811.277.656.262.500.126.550.200 D08.811.277.656.300.200.126.550.200 D12.644.360.075.405.550.200 D12.776.476.075.405.550.200
|
Concept/Terms |
Caspase 2- Caspase 2
- ICH-1 Protease
- ICH 1 Protease
- Caspase-2
Procaspase-2- Procaspase-2
- Procaspase 2
- Pro-Caspase-2
- Pro Caspase 2
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Below are MeSH descriptors whose meaning is more general than "Caspase 2".
Below are MeSH descriptors whose meaning is more specific than "Caspase 2".
This graph shows the total number of publications written about "Caspase 2" by people in this website by year, and whether "Caspase 2" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1998 | 0 | 1 | 1 |
1999 | 0 | 2 | 2 |
2000 | 0 | 1 | 1 |
2006 | 0 | 3 | 3 |
2009 | 1 | 0 | 1 |
2010 | 2 | 0 | 2 |
2011 | 1 | 0 | 1 |
2012 | 0 | 2 | 2 |
2013 | 1 | 2 | 3 |
2014 | 0 | 1 | 1 |
2015 | 0 | 1 | 1 |
2016 | 1 | 0 | 1 |
2017 | 2 | 0 | 2 |
2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Caspase 2" by people in Profiles.
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Caspase-2 regulates S-phase cell cycle events to protect from DNA damage accumulation independent of apoptosis. Oncogene. 2022 01; 41(2):204-219.
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The nucleolus: A new home for the PIDDosome. Cell Cycle. 2017; 16(17):1562-1563.
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NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus. J Cell Biol. 2017 06 05; 216(6):1795-1810.
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Caspase-2-mediated cell death is required for deleting aneuploid cells. Oncogene. 2017 05 11; 36(19):2704-2714.
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Coamplification of Myc/Pvt1 and homozygous deletion of Nlrp1 locus are frequent genetics changes in mouse osteosarcoma. Genes Chromosomes Cancer. 2015 Dec; 54(12):796-808.
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BH3-only protein BIM mediates heat shock-induced apoptosis. PLoS One. 2014; 9(1):e84388.
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Metabolic activation of CaMKII by coenzyme A. Mol Cell. 2013 Nov 07; 52(3):325-39.
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Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice. Cell Death Differ. 2013 Sep; 20(9):1174-82.
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Metabolic regulation of CaMKII protein and caspases in Xenopus laevis egg extracts. J Biol Chem. 2013 Mar 29; 288(13):8838-48.
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PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling. Mol Cell. 2012 Sep 14; 47(5):681-93.