"Caspase 10" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A long pro-domain caspase that contains a death effector domain in its pro-domain region. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS. Caspase 10 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.
| Descriptor ID |
D053455
|
| MeSH Number(s) |
D08.811.277.656.262.500.126.550.910 D08.811.277.656.300.200.126.550.910 D12.644.360.075.405.550.910 D12.776.476.075.405.550.910
|
| Concept/Terms |
Caspase 10a- Caspase 10a
- Mch4 Protease
- Protease, Mch4
- Caspase 10-a
- Caspase 10 a
|
Below are MeSH descriptors whose meaning is more general than "Caspase 10".
Below are MeSH descriptors whose meaning is more specific than "Caspase 10".
This graph shows the total number of publications written about "Caspase 10" by people in this website by year, and whether "Caspase 10" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 3 | 3 |
| 2004 | 0 | 2 | 2 |
| 2006 | 0 | 2 | 2 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "Caspase 10" by people in Profiles.
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TRAIL induces autophagic protein cleavage through caspase activation in melanoma cell lines under arginine deprivation. Mol Cell Biochem. 2013 Feb; 374(1-2):181-90.
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Caspase-10-mediated heat shock protein 90 beta cleavage promotes UVB irradiation-induced cell apoptosis. Mol Cell Biol. 2009 Jul; 29(13):3657-64.
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Genetic variants and haplotypes of the caspase-8 and caspase-10 genes contribute to susceptibility to cutaneous melanoma. Hum Mutat. 2008 Dec; 29(12):1443-51.
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Genetic variation and decreased risk for obesity in the Atherosclerosis Risk in Communities Study. Diabetes Obes Metab. 2007 Jul; 9(4):548-57.
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The important role of caspase-10 in sodium butyrate-induced apoptosis. Kobe J Med Sci. 2007; 53(5):265-73.
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Adrenomedullin 2 antagonist infusion to rats during midgestation causes fetoplacental growth restriction through apoptosis. Biol Reprod. 2006 Dec; 75(6):940-7.
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The initiator caspase, caspase-10beta, and the BH-3-only molecule, Bid, demonstrate evolutionary conservation in Xenopus of their pro-apoptotic activities in the extrinsic and intrinsic pathways. Genes Cells. 2006 Jul; 11(7):701-17.
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The adaptor molecule FADD from Xenopus laevis demonstrates evolutionary conservation of its pro-apoptotic activity. Genes Cells. 2004 Dec; 9(12):1249-64.
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Aberrant morphology, proliferation, and apoptosis of B-cell chronic lymphocytic leukemia cells. Hematology. 2004 Aug; 9(4):279-86.
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Caspase 10 levels are increased following DNA damage in a p53-dependent manner. Cancer Biol Ther. 2003 Nov-Dec; 2(6):707-12.