"Caspase 8" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS.
| Descriptor ID |
D053181
|
| MeSH Number(s) |
D08.811.277.656.262.500.126.550.800 D08.811.277.656.300.200.126.550.800 D12.644.360.024.285.037 D12.644.360.075.405.550.800 D12.644.360.075.421.037 D12.776.157.057.018.037 D12.776.476.024.320.025 D12.776.476.075.405.550.800 D12.776.476.075.421.037
|
| Concept/Terms |
Caspase 8- Caspase 8
- FLICE Protein
- Mch5 Protease
- Caspase-8
- CAP4 Protease
- MACH Protein
Procaspase-8- Procaspase-8
- Procaspase 8
- Pro-Caspase-8
- Pro Caspase 8
|
Below are MeSH descriptors whose meaning is more general than "Caspase 8".
Below are MeSH descriptors whose meaning is more specific than "Caspase 8".
This graph shows the total number of publications written about "Caspase 8" by people in this website by year, and whether "Caspase 8" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 2 | 2 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 2 | 3 |
| 2011 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 1 | 1 | 2 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Caspase 8" by people in Profiles.
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Mitochondria-Targeting Type-I Photodrug: Harnessing Caspase-3 Activity for Pyroptotic Oncotherapy. J Am Chem Soc. 2024 04 03; 146(13):9413-9421.
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Poly(ADP-ribose) polymerase-2 is essential for endometrial receptivity and blastocyst implantation, and regulated by caspase-8. Mol Cell Endocrinol. 2020 12 01; 518:110946.
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Characterization and Inception of a Triterpenoid Astrakurkurol, as a Cytotoxic Molecule on Human Hepatocellular Carcinoma Cells, Hep3B. J Agric Food Chem. 2019 Jul 10; 67(27):7660-7673.
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Mitochondrial DNA oxidation induces imbalanced activity of NLRP3/NLRP6 inflammasomes by activation of caspase-8 and BRCC36 in dry eye. J Autoimmun. 2017 Jun; 80:65-76.
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Integrated genomic and molecular characterization of cervical cancer. Nature. 2017 03 16; 543(7645):378-384.
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Alternaria extract activates autophagy that induces IL-18 release from airway epithelial cells. Biochem Biophys Res Commun. 2015 Sep 04; 464(4):969-974.
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Synergistic targeting of AML stem/progenitor cells with IAP antagonist birinapant and demethylating agents. J Natl Cancer Inst. 2014 Feb; 106(2):djt440.
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Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers. Cancer Discov. 2013 Jul; 3(7):770-81.
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Development of a high-throughput screen targeting caspase-8-mediated cleavage of the amyloid precursor protein. Anal Biochem. 2012 Feb 15; 421(2):467-76.
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Cell-surface galectin-3 confers resistance to TRAIL by impeding trafficking of death receptors in metastatic colon adenocarcinoma cells. Cell Death Differ. 2012 Mar; 19(3):523-33.