"Caspase 8" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS.
| Descriptor ID |
D053181
|
| MeSH Number(s) |
D08.811.277.656.262.500.126.550.800 D08.811.277.656.300.200.126.550.800 D12.644.360.024.285.037 D12.644.360.075.405.550.800 D12.644.360.075.421.037 D12.776.157.057.018.037 D12.776.476.024.320.025 D12.776.476.075.405.550.800 D12.776.476.075.421.037
|
| Concept/Terms |
Caspase 8- Caspase 8
- FLICE Protein
- Mch5 Protease
- Caspase-8
- CAP4 Protease
- MACH Protein
Procaspase-8- Procaspase-8
- Procaspase 8
- Pro-Caspase-8
- Pro Caspase 8
|
Below are MeSH descriptors whose meaning is more general than "Caspase 8".
Below are MeSH descriptors whose meaning is more specific than "Caspase 8".
This graph shows the total number of publications written about "Caspase 8" by people in this website by year, and whether "Caspase 8" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 2 | 2 |
| 2010 | 1 | 1 | 2 |
| 2011 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 1 | 1 | 2 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Caspase 8" by people in Profiles.
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miRNA-149 targets PARP-2 in endometrial epithelial and stromal cells to regulate the trophoblast attachment process. Mol Hum Reprod. 2021 05 29; 27(6).
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Caspase-8 loss radiosensitizes head and neck squamous cell carcinoma to SMAC mimetic-induced necroptosis. JCI Insight. 2020 12 03; 5(23).
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Poly(ADP-ribose) polymerase-2 is essential for endometrial receptivity and blastocyst implantation, and regulated by caspase-8. Mol Cell Endocrinol. 2020 12 01; 518:110946.
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Tumor suppressor death-associated protein kinase 1 inhibits necroptosis by p38 MAPK activation. Cell Death Dis. 2020 05 04; 11(5):305.
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Characterization and Inception of a Triterpenoid Astrakurkurol, as a Cytotoxic Molecule on Human Hepatocellular Carcinoma Cells, Hep3B. J Agric Food Chem. 2019 Jul 10; 67(27):7660-7673.
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Mutation allele frequency threshold does not affect prognostic analysis using next-generation sequencing in oral squamous cell carcinoma. BMC Cancer. 2018 Jul 24; 18(1):758.
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Distinct pattern of TP53 mutations in human immunodeficiency virus-related head and neck squamous cell carcinoma. Cancer. 2018 Jan 01; 124(1):84-94.
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Mitochondrial DNA oxidation induces imbalanced activity of NLRP3/NLRP6 inflammasomes by activation of caspase-8 and BRCC36 in dry eye. J Autoimmun. 2017 Jun; 80:65-76.
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Integrated genomic and molecular characterization of cervical cancer. Nature. 2017 03 16; 543(7645):378-384.
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Silencing the epigenetic silencer KDM4A for TRAIL and DR5 simultaneous induction and antitumor therapy. Cell Death Differ. 2016 11 01; 23(11):1886-1896.