CRADD Signaling Adaptor Protein
"CRADD Signaling Adaptor Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A death domain receptor signaling adaptor protein that plays a role in signaling the activation of INITIATOR CASPASES such as CASPASE 2. It contains a death domain that is specific for RIP SERINE-THEONINE KINASES and a caspase-binding domain that binds to and activates CASPASES such as CASPASE 2.
| Descriptor ID |
D053420
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| MeSH Number(s) |
D12.644.360.024.131.186 D12.644.360.024.285.050 D12.644.360.024.500.050 D12.644.360.075.358.186 D12.644.360.075.421.050 D12.776.157.057.006.186 D12.776.157.057.018.050 D12.776.157.057.500.050 D12.776.476.024.139.186 D12.776.476.024.320.050 D12.776.476.024.500.050 D12.776.476.075.358.186 D12.776.476.075.421.050
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| Concept/Terms |
CRADD Signaling Adaptor Protein- CRADD Signaling Adaptor Protein
- RIP-Associated Protein With a Death Domain
- RIP Associated Protein With a Death Domain
- RAIDD Signaling Adaptor Protein
- Caspase and Rip Adaptor with Death Domain Protein
|
Below are MeSH descriptors whose meaning is more general than "CRADD Signaling Adaptor Protein".
Below are MeSH descriptors whose meaning is more specific than "CRADD Signaling Adaptor Protein".
This graph shows the total number of publications written about "CRADD Signaling Adaptor Protein" by people in this website by year, and whether "CRADD Signaling Adaptor Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "CRADD Signaling Adaptor Protein" by people in Profiles.
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NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus. J Cell Biol. 2017 06 05; 216(6):1795-1810.
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PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling. Mol Cell. 2012 Sep 14; 47(5):681-93.
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Genetic mapping and exome sequencing identify variants associated with five novel diseases. PLoS One. 2012; 7(1):e28936.
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Characterization of cytoplasmic caspase-2 activation by induced proximity. Mol Cell. 2009 Sep 24; 35(6):830-40.
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Heat shock induces apoptosis independently of any known initiator caspase-activating complex. J Biol Chem. 2006 Jun 23; 281(25):16991-17000.