TNF Receptor-Associated Factor 2
"TNF Receptor-Associated Factor 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A signal transducing tumor necrosis factor receptor associated factor that is involved in TNF RECEPTOR feedback regulation. It is similar in structure and appears to work in conjunction with TNF RECEPTOR-ASSOCIATED FACTOR 1 to inhibit APOPTOSIS.
| Descriptor ID |
D047992
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| MeSH Number(s) |
D12.644.360.024.500.750 D12.776.157.057.500.750 D12.776.476.024.500.750
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "TNF Receptor-Associated Factor 2".
Below are MeSH descriptors whose meaning is more specific than "TNF Receptor-Associated Factor 2".
This graph shows the total number of publications written about "TNF Receptor-Associated Factor 2" by people in this website by year, and whether "TNF Receptor-Associated Factor 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 2 | 0 | 2 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "TNF Receptor-Associated Factor 2" by people in Profiles.
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Reversible Transgene Expression Reduces Fratricide and Permits 4-1BB Costimulation of CAR T Cells Directed to T-cell Malignancies. Cancer Immunol Res. 2018 01; 6(1):47-58.
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Comprehensive Modeling and Discovery of Mebendazole as a Novel TRAF2- and NCK-interacting Kinase Inhibitor. Sci Rep. 2016 09 21; 6:33534.
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Comparison of the peptide binding preferences of three closely related TRAF paralogs: TRAF2, TRAF3, and TRAF5. Protein Sci. 2016 07; 25(7):1273-89.
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The tumour suppressor Ras-association domain family protein 1A (RASSF1A) regulates TNF-a signalling in cardiomyocytes. Cardiovasc Res. 2014 Jul 01; 103(1):47-59.
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Constitutional tandem duplication of 9q34 that truncates EHMT1 in a child with ganglioglioma. Pediatr Blood Cancer. 2012 May; 58(5):801-5.
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Constitutive BR3 receptor signaling in diffuse, large B-cell lymphomas stabilizes nuclear factor-?B-inducing kinase while activating both canonical and alternative nuclear factor-?B pathways. Blood. 2011 Jan 06; 117(1):200-10.
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Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation. J Biol Chem. 2010 Feb 19; 285(8):5347-60.
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Positive and negative signaling components involved in TNFalpha-induced NF-kappaB activation. Cytokine. 2008 Jan; 41(1):1-8.
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Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappaB activation and proliferation in human head and neck squamous cell carcinoma. Oncogene. 2007 Mar 01; 26(10):1385-97.
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Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation. Mol Cell Biol. 2005 May; 25(10):3886-95.