TNF Receptor-Associated Factor 2
"TNF Receptor-Associated Factor 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A signal transducing tumor necrosis factor receptor associated factor that is involved in TNF RECEPTOR feedback regulation. It is similar in structure and appears to work in conjunction with TNF RECEPTOR-ASSOCIATED FACTOR 1 to inhibit APOPTOSIS.
| Descriptor ID |
D047992
|
| MeSH Number(s) |
D12.644.360.024.500.750 D12.776.157.057.500.750 D12.776.476.024.500.750
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "TNF Receptor-Associated Factor 2".
Below are MeSH descriptors whose meaning is more specific than "TNF Receptor-Associated Factor 2".
This graph shows the total number of publications written about "TNF Receptor-Associated Factor 2" by people in this website by year, and whether "TNF Receptor-Associated Factor 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 2 | 0 | 2 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "TNF Receptor-Associated Factor 2" by people in Profiles.
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TRAF2 regulates T cell immunity by maintaining a Tpl2-ERK survival signaling axis in effector and memory CD8 T cells. Cell Mol Immunol. 2021 09; 18(9):2262-2274.
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Tumor necrosis factor-a triggers opposing signals in head and neck squamous cell carcinoma and induces apoptosis via mitochondrial- and non-mitochondrial-dependent pathways. Int J Oncol. 2019 Dec; 55(6):1324-1338.
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Reversible Transgene Expression Reduces Fratricide and Permits 4-1BB Costimulation of CAR T Cells Directed to T-cell Malignancies. Cancer Immunol Res. 2018 01; 6(1):47-58.
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Comprehensive Modeling and Discovery of Mebendazole as a Novel TRAF2- and NCK-interacting Kinase Inhibitor. Sci Rep. 2016 09 21; 6:33534.
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Comparison of the peptide binding preferences of three closely related TRAF paralogs: TRAF2, TRAF3, and TRAF5. Protein Sci. 2016 07; 25(7):1273-89.
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TRAF2-mediated Lys63-linked ubiquitination of DUSP14/MKP6 is essential for its phosphatase activity. Cell Signal. 2016 Jan; 28(1):145-51.
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Genetic variation in the TNF/TRAF2/ASK1/p38 kinase signaling pathway as markers for postoperative pulmonary complications in lung cancer patients. Sci Rep. 2015 Jul 13; 5:12068.
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FKBP51 employs both scaffold and isomerase functions to promote NF-?B activation in melanoma. Nucleic Acids Res. 2015 Aug 18; 43(14):6983-93.
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Proinflammatory TLR signalling is regulated by a TRAF2-dependent proteolysis mechanism in macrophages. Nat Commun. 2015 Jan 07; 6:5930.
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HGK/MAP4K4 deficiency induces TRAF2 stabilization and Th17 differentiation leading to insulin resistance. Nat Commun. 2014 Aug 06; 5:4602.