CASP8 and FADD-Like Apoptosis Regulating Protein
"CASP8 and FADD-Like Apoptosis Regulating Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An APOPTOSIS-regulating protein that is structurally related to CASPASE 8 and competes with CASPASE 8 for binding to FAS ASSOCIATED DEATH DOMAIN PROTEIN. Two forms of CASP8 and FADD-like apoptosis regulating protein exist, a long form containing a caspase-like enzymatically inactive domain and a short form which lacks the caspase-like domain.
| Descriptor ID |
D053446
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| MeSH Number(s) |
D12.644.360.024.285.024 D12.644.360.024.500.024 D12.644.360.075.421.024 D12.776.157.057.018.024 D12.776.476.075.421.024
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "CASP8 and FADD-Like Apoptosis Regulating Protein".
Below are MeSH descriptors whose meaning is more specific than "CASP8 and FADD-Like Apoptosis Regulating Protein".
This graph shows the total number of publications written about "CASP8 and FADD-Like Apoptosis Regulating Protein" by people in this website by year, and whether "CASP8 and FADD-Like Apoptosis Regulating Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
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Below are the most recent publications written about "CASP8 and FADD-Like Apoptosis Regulating Protein" by people in Profiles.
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Genetic and Pharmacological Screens Converge in Identifying FLIP, BCL2, and IAP Proteins as Key Regulators of Sensitivity to the TRAIL-Inducing Anticancer Agent ONC201/TIC10. Cancer Res. 2015 Apr 15; 75(8):1668-74.
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Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer. Cell. 2013 Oct 24; 155(3):552-66.
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The histone deacetylase inhibitor, MS-275 (entinostat), downregulates c-FLIP, sensitizes osteosarcoma cells to FasL, and induces the regression of osteosarcoma lung metastases. Curr Cancer Drug Targets. 2013 May; 13(4):411-22.
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Antiviral protection against enterovirus 71 mediated by autophagy induction following FLICE-inhibitory protein inactivation. Virus Res. 2012 Oct; 169(1):316-20.
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Chemoprevention of colorectal cancer by targeting APC-deficient cells for apoptosis. Nature. 2010 Apr 15; 464(7291):1058-61.
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Protection of human pancreatic islets using a lentiviral vector expressing two genes: cFLIP and GFP. Cell Transplant. 2008; 17(7):793-802.
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Gangliosides contribute to stability of paranodal junctions and ion channel clusters in myelinated nerve fibers. Glia. 2007 May; 55(7):746-57.
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c-FLIP confers resistance to FAS-mediated apoptosis in anaplastic large-cell lymphoma. Blood. 2006 Mar 15; 107(6):2544-7.
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CNP is required for maintenance of axon-glia interactions at nodes of Ranvier in the CNS. Glia. 2005 Apr 01; 50(1):86-90.
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I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis. J Biol Chem. 1997 Jul 11; 272(28):17255-7.