"Caspase 9" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A long pro-domain caspase that contains a CASPASE RECRUITMENT DOMAIN in its pro-domain region. Caspase 9 is activated during cell stress by mitochondria-derived proapoptotic factors and by CARD SIGNALING ADAPTOR PROTEINS such as APOPTOTIC PROTEASE-ACTIVATING FACTOR 1. It activates APOPTOSIS by cleaving and activating EFFECTOR CASPASES.
| Descriptor ID |
D053453
|
| MeSH Number(s) |
D08.811.277.656.262.500.126.550.900 D08.811.277.656.300.200.126.550.900 D12.644.360.024.131.155 D12.644.360.075.358.155 D12.644.360.075.405.550.900 D12.776.157.057.006.155 D12.776.476.024.139.155 D12.776.476.075.358.155 D12.776.476.075.405.550.900
|
| Concept/Terms |
Caspase 9- Caspase 9
- ICE-Like Apoptotic Protease 6
- ICE Like Apoptotic Protease 6
- Apoptotic Protease Activating Factor 3
- ICE-LAP6 Protein
- ICE LAP6 Protein
- Caspase-9
Procaspase-9- Procaspase-9
- Procaspase 9
- Pro-Caspase-9
- Pro Caspase 9
|
Below are MeSH descriptors whose meaning is more general than "Caspase 9".
Below are MeSH descriptors whose meaning is more specific than "Caspase 9".
This graph shows the total number of publications written about "Caspase 9" by people in this website by year, and whether "Caspase 9" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 3 | 3 |
| 2007 | 2 | 0 | 2 |
| 2008 | 2 | 0 | 2 |
| 2009 | 1 | 0 | 1 |
| 2010 | 3 | 1 | 4 |
| 2011 | 2 | 0 | 2 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 2 | 2 |
| 2014 | 2 | 0 | 2 |
| 2015 | 6 | 1 | 7 |
| 2016 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "Caspase 9" by people in Profiles.
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Maintenance of Germinal Center B Cells by Caspase-9 through Promotion of Apoptosis and Inhibition of Necroptosis. J Immunol. 2020 07 01; 205(1):113-120.
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A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure. Hum Mol Genet. 2019 Aug 01; 28(15):2615-2633.
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Cord blood NK cells engineered to express IL-15 and a CD19-targeted CAR show long-term persistence and potent antitumor activity. Leukemia. 2018 02; 32(2):520-531.
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Induction of apoptotic DNA fragmentation mediated by mitochondrial pathway with caspase-3-dependent BID cleavage in human gastric cancer cells by a new nitroxyl spin-labeled derivative of podophyllotoxin. Biomed Pharmacother. 2017 Jun; 90:131-138.
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The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities. Nat Commun. 2016 11 24; 7:13565.
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Redirecting Specificity of T cells Using the Sleeping Beauty System to Express Chimeric Antigen Receptors by Mix-and-Matching of VL and VH Domains Targeting CD123+ Tumors. PLoS One. 2016; 11(8):e0159477.
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Improving the safety of T-Cell therapies using an inducible caspase-9 gene. Exp Hematol. 2016 Nov; 44(11):1013-1019.
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Pyroptosis as a Regulated Form of Necrosis: PI+/Annexin V-/High Caspase 1/Low Caspase 9 Activity in Cells = Pyroptosis? Circ Res. 2016 05 13; 118(10):1457-60.
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Serial Activation of the Inducible Caspase 9 Safety Switch After Human Stem Cell Transplantation. Mol Ther. 2016 Apr; 24(4):823-31.
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Clonal Dynamics In Vivo of Virus Integration Sites of T Cells Expressing a Safety Switch. Mol Ther. 2016 04; 24(4):736-45.