Apoptotic Protease-Activating Factor 1
"Apoptotic Protease-Activating Factor 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A CARD signaling adaptor protein characterized by an N-terminal CARD DOMAIN and C-terminal WD40 REPEATS. It plays a role in the mitochondria-stimulated apoptosis (APOPTOSIS, INTRINSIC PATHWAY) and binds to CYTOCHROME C in the CYTOSOL to form an APOPTOSOMAL PROTEIN COMPLEX which activates INITIATOR CASPASES such as CASPASE 9.
| Descriptor ID |
D053477
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| MeSH Number(s) |
D12.644.360.024.131.124 D12.644.360.075.358.124 D12.776.157.057.006.124 D12.776.476.024.139.124 D12.776.476.075.358.124
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| Concept/Terms |
Apoptotic Protease-Activating Factor 1- Apoptotic Protease-Activating Factor 1
- Apoptotic Protease Activating Factor 1
- Apaf-1 Protease-Activating Factor
- Apaf 1 Protease Activating Factor
- Protease-Activating Factor, Apaf-1
- Apoptotic Peptidase Activating Factor 1
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Below are MeSH descriptors whose meaning is more general than "Apoptotic Protease-Activating Factor 1".
Below are MeSH descriptors whose meaning is more specific than "Apoptotic Protease-Activating Factor 1".
This graph shows the total number of publications written about "Apoptotic Protease-Activating Factor 1" by people in this website by year, and whether "Apoptotic Protease-Activating Factor 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 2 | 2 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 7 | 7 |
| 2001 | 0 | 3 | 3 |
| 2002 | 0 | 2 | 2 |
| 2004 | 0 | 1 | 1 |
| 2005 | 1 | 2 | 3 |
| 2006 | 0 | 3 | 3 |
| 2007 | 1 | 0 | 1 |
| 2009 | 1 | 1 | 2 |
| 2010 | 1 | 0 | 1 |
| 2011 | 2 | 1 | 3 |
| 2016 | 2 | 0 | 2 |
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Below are the most recent publications written about "Apoptotic Protease-Activating Factor 1" by people in Profiles.
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The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities. Nat Commun. 2016 11 24; 7:13565.
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Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1. Nat Commun. 2016 Mar 29; 7:11150.
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The holo-apoptosome: activation of procaspase-9 and interactions with caspase-3. Structure. 2011 Aug 10; 19(8):1084-96.
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IL-24 gene transfer sensitizes melanoma cells to erlotinib through modulation of the Apaf-1 and Akt signaling pathways. Melanoma Res. 2011 Feb; 21(1):44-56.
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Defective molecular timer in the absence of nucleotides leads to inefficient caspase activation. PLoS One. 2011 Jan 27; 6(1):e16379.
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Regulation of the Apaf-1-caspase-9 apoptosome. J Cell Sci. 2010 Oct 01; 123(Pt 19):3209-14.
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Characterization of cytoplasmic caspase-2 activation by induced proximity. Mol Cell. 2009 Sep 24; 35(6):830-40.
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The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer. EMBO J. 2009 Jul 08; 28(13):1916-25.
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Synergistic tumor suppression by coexpression of FUS1 and p53 is associated with down-regulation of murine double minute-2 and activation of the apoptotic protease-activating factor 1-dependent apoptotic pathway in human non-small cell lung cancer cells. Cancer Res. 2007 Jan 15; 67(2):709-17.
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Intracellular nucleotides act as critical prosurvival factors by binding to cytochrome C and inhibiting apoptosome. Cell. 2006 Jun 30; 125(7):1333-46.