Unfolded Protein Response
"Unfolded Protein Response" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cellular response to environmental insults that cause disruptions in PROTEIN FOLDING and/or accumulation of defectively folded protein in the ENDOPLASMIC RETICULUM. It consists of a group of regulatory cascades that are triggered as a response to altered levels of calcium and/or the redox state of the endoplasmic reticulum. Persistent activation of the unfolded protein response leads to the induction of APOPTOSIS.
| Descriptor ID |
D056811
|
| MeSH Number(s) |
G02.111.660.871.790.600.962 G02.111.691.600.850 G03.734.871.790.600.850 G05.308.670.600.850
|
| Concept/Terms |
Unfolded Protein Response- Unfolded Protein Response
- Protein Response, Unfolded
- Protein Responses, Unfolded
- Response, Unfolded Protein
- Responses, Unfolded Protein
- Unfolded Protein Responses
|
Below are MeSH descriptors whose meaning is more general than "Unfolded Protein Response".
Below are MeSH descriptors whose meaning is more specific than "Unfolded Protein Response".
This graph shows the total number of publications written about "Unfolded Protein Response" by people in this website by year, and whether "Unfolded Protein Response" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 2 | 0 | 2 |
| 2012 | 0 | 2 | 2 |
| 2013 | 0 | 2 | 2 |
| 2014 | 0 | 2 | 2 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 2 | 3 | 5 |
| 2018 | 3 | 7 | 10 |
| 2019 | 0 | 1 | 1 |
| 2020 | 2 | 1 | 3 |
| 2021 | 0 | 1 | 1 |
| 2023 | 1 | 1 | 2 |
| 2024 | 0 | 1 | 1 |
| 2025 | 0 | 1 | 1 |
| 2026 | 1 | 2 | 3 |
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Below are the most recent publications written about "Unfolded Protein Response" by people in Profiles.
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A model of the aged lung epithelium in idiopathic pulmonary fibrosis. Aging (Albany NY). 2021 07 08; 13(13):16922-16937.
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Cholesterol-Induced Phenotypic Modulation of Smooth Muscle Cells to Macrophage/Fibroblast-like Cells Is Driven by an Unfolded Protein Response. Arterioscler Thromb Vasc Biol. 2021 01; 41(1):302-316.
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Vitamin D Receptor Activation in Liver Macrophages Protects Against Hepatic Endoplasmic Reticulum Stress in Mice. Hepatology. 2020 04; 71(4):1453-1466.
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Heterozygous Truncating Variants in POMP Escape Nonsense-Mediated Decay and Cause a Unique Immune Dysregulatory Syndrome. Am J Hum Genet. 2018 06 07; 102(6):1126-1142.
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Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer. J Clin Invest. 2018 04 02; 128(4):1283-1299.
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ERa promotes murine hematopoietic regeneration through the Ire1a-mediated unfolded protein response. Elife. 2018 02 16; 7.
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Microbial Genetic Composition Tunes Host Longevity. Cell. 2017 Jun 15; 169(7):1249-1262.e13.
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Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis. Cell Metab. 2014 Sep 02; 20(3):471-82.
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Identification of signaling pathways modulated by RHBDD2 in breast cancer cells: a link to the unfolded protein response. Cell Stress Chaperones. 2014 May; 19(3):379-88.
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AKI after conditional and kidney-specific knockdown of stanniocalcin-1. J Am Soc Nephrol. 2014 Oct; 25(10):2303-15.