"Protein Prenylation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A post-translational modification of proteins by the attachment of an isoprenoid to the C-terminal cysteine residue. The isoprenoids used, farnesyl diphosphate or geranylgeranyl diphosphate, are derived from the same biochemical pathway that produces cholesterol.
| Descriptor ID |
D017368
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| MeSH Number(s) |
G02.111.660.871.790.600.400 G02.111.672.500 G02.111.691.600.400 G03.734.871.790.600.400 G03.804.500 G05.308.670.600.400
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Protein Prenylation".
Below are MeSH descriptors whose meaning is more specific than "Protein Prenylation".
This graph shows the total number of publications written about "Protein Prenylation" by people in this website by year, and whether "Protein Prenylation" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Protein Prenylation" by people in Profiles.
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Intracellular lipid surveillance by small G protein geranylgeranylation. Nature. 2022 05; 605(7911):736-740.
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Targeting Krasg12c -mutant cancer with a mutation-specific inhibitor. J Intern Med. 2020 08; 288(2):183-191.
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Metabolic model for diversity-generating biosynthesis. Proc Natl Acad Sci U S A. 2016 Feb 16; 113(7):1772-7.
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Drosophila Tempura, a novel protein prenyltransferase a subunit, regulates notch signaling via Rab1 and Rab11. PLoS Biol. 2014 Jan; 12(1):e1001777.
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Breast cancer cell targeting by prenylation inhibitors elucidated in living animals with a bioluminescence reporter. Clin Cancer Res. 2012 Aug 01; 18(15):4136-44.
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Microvascular endothelial cell responses in vitro and in vivo: modulation by zoledronic acid and paclitaxel? J Vasc Res. 2010; 47(6):481-93.
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Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy. Mol Cell Biol. 2009 Apr; 29(8):2254-63.
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The bisphosphonate zoledronic acid decreases tumor growth in bone in mice with defective osteoclasts. Bone. 2009 May; 44(5):908-16.
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Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division. J Cell Biol. 2008 May 05; 181(3):485-96.
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Farnesyl transferase inhibitor resistance probed by target mutagenesis. Blood. 2007 Sep 15; 110(6):2102-9.