"Protein Prenylation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A post-translational modification of proteins by the attachment of an isoprenoid to the C-terminal cysteine residue. The isoprenoids used, farnesyl diphosphate or geranylgeranyl diphosphate, are derived from the same biochemical pathway that produces cholesterol.
| Descriptor ID |
D017368
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| MeSH Number(s) |
G02.111.660.871.790.600.400 G02.111.672.500 G02.111.691.600.400 G03.734.871.790.600.400 G03.804.500 G05.308.670.600.400
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Protein Prenylation".
Below are MeSH descriptors whose meaning is more specific than "Protein Prenylation".
This graph shows the total number of publications written about "Protein Prenylation" by people in this website by year, and whether "Protein Prenylation" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Protein Prenylation" by people in Profiles.
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Intracellular lipid surveillance by small G protein geranylgeranylation. Nature. 2022 05; 605(7911):736-740.
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Analogs of farnesyl diphosphate alter CaaX substrate specificity and reactions rates of protein farnesyltransferase. Bioorg Med Chem Lett. 2016 Feb 15; 26(4):1333-6.
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Drosophila Tempura, a novel protein prenyltransferase a subunit, regulates notch signaling via Rab1 and Rab11. PLoS Biol. 2014 Jan; 12(1):e1001777.
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Farnesyl transferase inhibitor resistance probed by target mutagenesis. Blood. 2007 Sep 15; 110(6):2102-9.
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Modulatory effects of HMG-CoA reductase inhibitors in diabetic microangiopathy. FASEB J. 2004 May; 18(7):805-15.
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3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/ p21 signaling pathway: Implications for diabetic nephropathy. Proc Natl Acad Sci U S A. 2002 Jun 11; 99(12):8301-5.
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Nerve growth factor induces a succession of increases in isoprenylated methylated small GTP-binding proteins of PC-12 pheochromocytoma cells. Neuropeptides. 1993 Jan; 24(1):11-25.
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Isoprenylation and carboxylmethylation in small GTP-binding proteins of pheochromocytoma (PC-12) cells. Cell Mol Neurobiol. 1992 Aug; 12(4):333-51.