"Patched-1 Receptor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A patched receptor for several HEDGEHOG PROTEINS that associates with the SMOOTHENED RECEPTOR to modulate hedgehog signaling. It is also a TUMOR SUPPRESSOR PROTEIN; mutations in the patched-1 gene are associated with BASAL CELL NEVUS SYNDROME; SQUAMOUS CELL CARCNIOMA of the ESOPHAGUS; trichoepitheliomas, and CARCINOMA, TRANSITIONAL CELL of the URINARY BLADDER.
| Descriptor ID |
D000072081
|
| MeSH Number(s) |
D12.776.543.750.058.500 D12.776.624.776.633.500
|
| Concept/Terms |
Patched-1 Receptor- Patched-1 Receptor
- Patched 1 Receptor
- Receptor, Patched-1
- PTCH1 Protein
- Patched Homolog-1
- Patched Homolog 1
- Patched-1 Protein
- Patched 1 Protein
- Patched Receptor-1
- Patched Receptor 1
- Receptor-1, Patched
|
Below are MeSH descriptors whose meaning is more general than "Patched-1 Receptor".
Below are MeSH descriptors whose meaning is more specific than "Patched-1 Receptor".
This graph shows the total number of publications written about "Patched-1 Receptor" by people in this website by year, and whether "Patched-1 Receptor" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2006 | 0 | 2 | 2 |
| 2007 | 0 | 2 | 2 |
| 2008 | 0 | 2 | 2 |
| 2009 | 0 | 4 | 4 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 6 | 6 |
| 2012 | 0 | 2 | 2 |
| 2014 | 0 | 3 | 3 |
| 2015 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 2 | 0 | 2 |
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Below are the most recent publications written about "Patched-1 Receptor" by people in Profiles.
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S100a4-Cre-mediated deletion of Patched1 causes hypogonadotropic hypogonadism: role of pituitary hematopoietic cells in endocrine regulation. JCI Insight. 2019 07 02; 5.
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Transcriptional repressor REST drives lineage stage-specific chromatin compaction at Ptch1 and increases AKT activation in a mouse model of medulloblastoma. Sci Signal. 2019 01 22; 12(565).
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A functional genomics approach to identify pathways of drug resistance in medulloblastoma. Acta Neuropathol Commun. 2018 12 27; 6(1):146.
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Sonic hedgehog protects endometrial hyperplasial cells against oxidative stress via suppressing mitochondrial fission protein dynamin-like GTPase (Drp1). Free Radic Biol Med. 2018 12; 129:582-599.
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Epithelial and non-epithelial Ptch1 play opposing roles to regulate proliferation and morphogenesis of the mouse mammary gland. Development. 2017 04 01; 144(7):1317-1327.
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Temporal and spatial expression patterns of Hedgehog receptors in the developing inner and middle ear. Int J Dev Biol. 2017; 61(8-9):557-563.
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Temozolomide resistance in glioblastoma occurs by miRNA-9-targeted PTCH1, independent of sonic hedgehog level. Oncotarget. 2015 Jan 20; 6(2):1190-201.
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PTCH1 expression at diagnosis predicts imatinib failure in chronic myeloid leukaemia patients in chronic phase. Am J Hematol. 2015 Jan; 90(1):20-6.
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Patched targeting peptides for imaging and treatment of hedgehog positive breast tumors. Biomed Res Int. 2014; 2014:525680.
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All-trans-retinoic acid antagonizes the Hedgehog pathway by inducing patched. Cancer Biol Ther. 2014 Apr; 15(4):463-72.