Retinoblastoma-Binding Protein 2
"Retinoblastoma-Binding Protein 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A retinoblastoma binding protein that is also a member of the Jumonji-domain histone demethylases. It has demethylation activity towards specific LYSINE residues found on HISTONE H3.
| Descriptor ID |
D056485
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| MeSH Number(s) |
D08.811.682.662.582.475.500.500 D08.811.682.690.416.388.200 D12.644.360.024.328.200 D12.776.157.057.158.200 D12.776.476.024.420.200 D12.776.660.769.200
|
| Concept/Terms |
Retinoblastoma-Binding Protein 2- Retinoblastoma-Binding Protein 2
- Retinoblastoma Binding Protein 2
- RBBP2 Protein
- Jumonji Domain-Containing Protein 1A
- Jumonji Domain Containing Protein 1A
- Jumonji, AT Rich Interactive Domain 1A
|
Below are MeSH descriptors whose meaning is more general than "Retinoblastoma-Binding Protein 2".
Below are MeSH descriptors whose meaning is more specific than "Retinoblastoma-Binding Protein 2".
This graph shows the total number of publications written about "Retinoblastoma-Binding Protein 2" by people in this website by year, and whether "Retinoblastoma-Binding Protein 2" was a major or minor topic of these publications.
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Below are the most recent publications written about "Retinoblastoma-Binding Protein 2" by people in Profiles.
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Histone demethylase KDM5 regulates cardiomyocyte maturation by promoting fatty acid oxidation, oxidative phosphorylation, and myofibrillar organization. Cardiovasc Res. 2024 May 07; 120(6):630-643.
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A novel KDM5A/MPC-1 signaling pathway promotes pancreatic cancer progression via redirecting mitochondrial pyruvate metabolism. Oncogene. 2020 01; 39(5):1140-1151.
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Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A. J Med Chem. 2018 12 13; 61(23):10588-10601.
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Insights into the Action of Inhibitor Enantiomers against Histone Lysine Demethylase 5A. J Med Chem. 2018 04 12; 61(7):3193-3208.
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KDM5 lysine demethylases are involved in maintenance of 3'UTR length. Sci Adv. 2016 Nov; 2(11):e1501662.
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PI3K/AKT Signaling Regulates H3K4 Methylation in Breast Cancer. Cell Rep. 2016 06 21; 15(12):2692-704.
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Drug-tolerant cancer cells show reduced tumor-initiating capacity: depletion of CD44 cells and evidence for epigenetic mechanisms. PLoS One. 2011; 6(9):e24397.