"Histone Demethylases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Enzymes that catalyse the removal of methyl groups from LYSINE or ARGININE residues found on HISTONES. Many histone demethylases generally function through an oxidoreductive mechanism.
| Descriptor ID |
D056466
|
| MeSH Number(s) |
D08.811.682.662.582.475
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Histone Demethylases".
Below are MeSH descriptors whose meaning is more specific than "Histone Demethylases".
This graph shows the total number of publications written about "Histone Demethylases" by people in this website by year, and whether "Histone Demethylases" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 5 | 5 |
| 2008 | 0 | 2 | 2 |
| 2009 | 0 | 3 | 3 |
| 2010 | 2 | 1 | 3 |
| 2011 | 2 | 0 | 2 |
| 2012 | 5 | 1 | 6 |
| 2013 | 1 | 4 | 5 |
| 2014 | 3 | 1 | 4 |
| 2015 | 6 | 3 | 9 |
| 2016 | 6 | 3 | 9 |
| 2017 | 2 | 2 | 4 |
| 2018 | 6 | 0 | 6 |
| 2019 | 2 | 0 | 2 |
| 2020 | 2 | 2 | 4 |
| 2021 | 1 | 3 | 4 |
| 2022 | 1 | 3 | 4 |
| 2023 | 2 | 3 | 5 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Histone Demethylases" by people in Profiles.
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LSD1 inhibition improves efficacy of adoptive T cell therapy by enhancing CD8+ T cell responsiveness. Nat Commun. 2024 Aug 27; 15(1):7366.
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Myeloid-specific KDM6B inhibition sensitizes glioblastoma to PD1 blockade. Nat Cancer. 2023 Oct; 4(10):1455-1473.
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Lysine-specific histone demethylase 1A (KDM1A/LSD1) inhibition attenuates DNA double-strand break repair and augments the efficacy of temozolomide in glioblastoma. Neuro Oncol. 2023 07 06; 25(7):1249-1261.
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Histone demethylase KDM5D upregulation drives sex differences in colon cancer. Nature. 2023 Jul; 619(7970):632-639.
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Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1. Blood Cancer J. 2023 04 13; 13(1):53.
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Loss of the Maternal Effect Gene Nlrp2 Alters the Transcriptome of Ovulated Mouse Oocytes and Impacts Expression of Histone Demethylase KDM1B. Reprod Sci. 2023 09; 30(9):2780-2793.
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Failure of human rhombic lip differentiation underlies medulloblastoma formation. Nature. 2022 09; 609(7929):1021-1028.
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De novo annotation of lncRNA HOTAIR transcripts by long-read RNA capture-seq reveals a differentiation-driven isoform switch. BMC Genomics. 2022 Sep 17; 23(1):658.
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PU.1 and MYC transcriptional network defines synergistic drug responses to KIT and LSD1 inhibition in acute myeloid leukemia. Leukemia. 2022 07; 36(7):1781-1793.
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Salt Sensitivity of Blood Pressure and Aldosterone: Interaction Between the Lysine-specific Demethylase 1 Gene, Sex, and Age. J Clin Endocrinol Metab. 2022 04 19; 107(5):1294-1302.