"Perilipin-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A lipid droplet protein that is expressed primarily by ADIPOCYTES of WHITE ADIPOSE TISSUE and BROWN ADIPOSE TISSUE. It co-localizes with MACROPHAGES and FOAM CELLS of artherosclerotic lesions and stabilizes LIPID DROPLETS by inhibiting HORMONE SENSITIVE LIPASE. It may also protect TRIGLYCERIDES against hydrolysis within the PLASMA MEMBRANE and modulate CHOLESTEROL ESTER HYDROLASE activity.
| Descriptor ID |
D000070778
|
| MeSH Number(s) |
D12.776.157.464.500.500
|
| Concept/Terms |
Perilipin-1- Perilipin-1
- Perilipin 1
- Perilipin A Protein
- Protein, Perilipin A
- PERI Protein
- Protein, PERI
- Perilipin
- Perilipin B Protein
- Protein, Perilipin B
- Perilipin Protein
- Protein, Perilipin
- Plin Protein
- Protein, Plin
|
Below are MeSH descriptors whose meaning is more general than "Perilipin-1".
Below are MeSH descriptors whose meaning is more specific than "Perilipin-1".
This graph shows the total number of publications written about "Perilipin-1" by people in this website by year, and whether "Perilipin-1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Perilipin-1" by people in Profiles.
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Impact of adrenomedullin blockage on lipid metabolism in female mice exposed to high-fat diet. Endocrine. 2019 08; 65(2):278-285.
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Differential phosphorylation of perilipin 1A at the initiation of lipolysis revealed by novel monoclonal antibodies and high content analysis. PLoS One. 2013; 8(2):e55511.
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The PAT family of lipid droplet proteins in heart and vascular cells. Curr Hypertens Rep. 2008 Dec; 10(6):461-6.
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Metabolic adaptations in the absence of perilipin: increased beta-oxidation and decreased hepatic glucose production associated with peripheral insulin resistance but normal glucose tolerance in perilipin-null mice. J Biol Chem. 2004 Aug 20; 279(34):35150-8.
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Coordinated upregulation of oxidative pathways and downregulation of lipid biosynthesis underlie obesity resistance in perilipin knockout mice: a microarray gene expression profile. Diabetes. 2003 Nov; 52(11):2666-74.
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The murine perilipin gene: the lipid droplet-associated perilipins derive from tissue-specific, mRNA splice variants and define a gene family of ancient origin. Mamm Genome. 2001 Sep; 12(9):741-9.
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Absence of perilipin results in leanness and reverses obesity in Lepr(db/db) mice. Nat Genet. 2000 Dec; 26(4):474-9.