Jumonji Domain-Containing Histone Demethylases
"Jumonji Domain-Containing Histone Demethylases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of histone demethylases that share a conserved Jumonji C domain. The enzymes function via an iron-dependent dioxygenase mechanism that couples the conversion of 2-oxoglutarate to succinate to the hydroxylation of N-methyl groups.
| Descriptor ID |
D056484
|
| MeSH Number(s) |
D08.811.682.662.582.475.500 D08.811.682.690.416.388
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Jumonji Domain-Containing Histone Demethylases".
Below are MeSH descriptors whose meaning is more specific than "Jumonji Domain-Containing Histone Demethylases".
This graph shows the total number of publications written about "Jumonji Domain-Containing Histone Demethylases" by people in this website by year, and whether "Jumonji Domain-Containing Histone Demethylases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2013 | 3 | 0 | 3 |
| 2014 | 3 | 2 | 5 |
| 2015 | 3 | 0 | 3 |
| 2017 | 1 | 1 | 2 |
| 2018 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 2 | 3 |
| 2021 | 1 | 1 | 2 |
| 2022 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Jumonji Domain-Containing Histone Demethylases" by people in Profiles.
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Myeloid-specific KDM6B inhibition sensitizes glioblastoma to PD1 blockade. Nat Cancer. 2023 Oct; 4(10):1455-1473.
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The clinical and molecular spectrum of the KDM6B-related neurodevelopmental disorder. Am J Hum Genet. 2023 06 01; 110(6):963-978.
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Cooperation between KDM6B overexpression and TET2 deficiency in the pathogenesis of chronic myelomonocytic leukemia. Leukemia. 2022 08; 36(8):2097-2107.
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Downregulation of the endothelial histone demethylase JMJD3 is associated with neointimal hyperplasia of arteriovenous fistulas in kidney failure. J Biol Chem. 2022 05; 298(5):101816.
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AR-negative prostate cancer is vulnerable to loss of JMJD1C demethylase. Proc Natl Acad Sci U S A. 2021 09 07; 118(36).
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Mechanistic insights into KDM4A driven genomic instability. Biochem Soc Trans. 2021 02 26; 49(1):93-105.
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Loss of H3K27 methylation identifies poor outcomes in adult-onset acute leukemia. Clin Epigenetics. 2021 01 28; 13(1):21.
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Mechanisms Regulating Muscle Protein Synthesis in CKD. J Am Soc Nephrol. 2020 11; 31(11):2573-2587.
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Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis. Cell Stem Cell. 2020 07 02; 27(1):81-97.e8.
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Mechanistic basis and efficacy of targeting the ?-catenin-TCF7L2-JMJD6-c-Myc axis to overcome resistance to BET inhibitors. Blood. 2020 04 09; 135(15):1255-1269.