Alpha-Ketoglutarate-Dependent Dioxygenase FTO
"Alpha-Ketoglutarate-Dependent Dioxygenase FTO" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. It has highest activity towards single-stranded RNA containing 3-methyluracil, followed by SINGLE-STRANDED DNA containing 3-methylthymine and specifically demethylates N(6)-methyladenosine (m6A) RNA, the most common internal modification of MESSENGER RNA (mRNA) in higher EUKARYOTES. It contributes to the regulation of the global metabolic rate, energy HOMEOSTASIS, as well as body fat accumulation by regulating the differentiation of ADIPOCYTES into BROWN FAT CELLS or WHITE FAT CELLS.
Descriptor ID |
D000071516
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MeSH Number(s) |
D08.811.074.062.968 D08.811.682.662.582.242 D08.811.682.690.416.139.992
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Concept/Terms |
Alpha-Ketoglutarate-Dependent Dioxygenase FTO- Alpha-Ketoglutarate-Dependent Dioxygenase FTO
- Alpha Ketoglutarate Dependent Dioxygenase FTO
- FTO, Alpha-Ketoglutarate-Dependent Dioxygenase
- Fat Mass and Obesity Associated (FTO) Protein
- Alpha-Ketoglutarate-Dependent Dioxygenase
- Alpha Ketoglutarate Dependent Dioxygenase
- Dioxygenase, Alpha-Ketoglutarate-Dependent
- Fat Mass and Obesity Associated Protein
- AlkB Homolog 9 Protein
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Below are MeSH descriptors whose meaning is more general than "Alpha-Ketoglutarate-Dependent Dioxygenase FTO".
Below are MeSH descriptors whose meaning is more specific than "Alpha-Ketoglutarate-Dependent Dioxygenase FTO".
This graph shows the total number of publications written about "Alpha-Ketoglutarate-Dependent Dioxygenase FTO" by people in this website by year, and whether "Alpha-Ketoglutarate-Dependent Dioxygenase FTO" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2008 | 0 | 1 | 1 |
2009 | 0 | 1 | 1 |
2010 | 0 | 2 | 2 |
2011 | 0 | 3 | 3 |
2012 | 0 | 2 | 2 |
2013 | 0 | 1 | 1 |
2014 | 0 | 1 | 1 |
2015 | 0 | 1 | 1 |
2016 | 3 | 1 | 4 |
2017 | 1 | 0 | 1 |
2018 | 0 | 1 | 1 |
2019 | 1 | 0 | 1 |
2020 | 0 | 1 | 1 |
2021 | 1 | 0 | 1 |
2022 | 1 | 1 | 2 |
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Below are the most recent publications written about "Alpha-Ketoglutarate-Dependent Dioxygenase FTO" by people in Profiles.
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Cerebroprotective Role of N6-Methyladenosine Demethylase FTO (Fat Mass and Obesity-Associated Protein) After Experimental Stroke. Stroke. 2023 01; 54(1):245-254.
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m6A RNA demethylase FTO promotes the growth, migration and invasion of pancreatic cancer cells through inhibiting TFPI-2. Epigenetics. 2022 12; 17(12):1738-1752.
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Comparison of potential inhibitors and targeting fat mass and obesity-associated protein causing diabesity through docking and molecular dynamics strategies. J Cell Biochem. 2021 11; 122(11):1625-1638.
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Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants. Nat Commun. 2020 10 14; 11(1):5182.
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Similarities in Metabolic Flexibility and Hunger Hormone Ghrelin Exist between FTO Gene Variants in Response to an Acute Dietary Challenge. Nutrients. 2019 Oct 18; 11(10).
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Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium. Mol Psychiatry. 2019 12; 24(12):1920-1932.
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Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. PLoS Genet. 2017 Apr; 13(4):e1006528.
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Common variants in the obesity-associated genes FTO and MC4R are not associated with risk of colorectal cancer. Cancer Epidemiol. 2016 10; 44:1-4.
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Important Role of FTO in the Survival of Rare Panresistant Triple-Negative Inflammatory Breast Cancer Cells Facing a Severe Metabolic Challenge. PLoS One. 2016; 11(7):e0159072.
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Selected single-nucleotide polymorphisms in FOXE1, SERPINA5, FTO, EVPL, TICAM1 and SCARB1 are associated with papillary and follicular thyroid cancer risk: replication study in a German population. Carcinogenesis. 2016 07; 37(7):677-684.