AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase
"AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dioxygenase and alkylation repair homolog that repairs alkylated DNA containing 1-methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. It has a strong preference for SINGLE-STRANDED DNA and may also act on RNA.
| Descriptor ID |
D000071500
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| MeSH Number(s) |
D08.811.074.062.875 D08.811.682.690.416.139.875
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| Concept/Terms |
AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase- AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase
- AlkB Homolog 3, Alpha Ketoglutarate Dependent Dioxygenase
- Prostate Cancer Antigen 1
- Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 3
- Alpha Ketoglutarate Dependent Dioxygenase AlkB Homolog 3
- Alkylated DNA Repair Protein AlkB Homolog 3
|
Below are MeSH descriptors whose meaning is more general than "AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase".
Below are MeSH descriptors whose meaning is more specific than "AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase".
This graph shows the total number of publications written about "AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase" by people in this website by year, and whether "AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase" was a major or minor topic of these publications.
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Below are the most recent publications written about "AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase" by people in Profiles.
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Aberrant RNA methylation triggers recruitment of an alkylation repair complex. Mol Cell. 2021 10 21; 81(20):4228-4242.e8.
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Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents. Cell Rep. 2015 Dec 22; 13(11):2353-2361.
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Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage. EMBO J. 2006 Jul 26; 25(14):3389-97.