DNA Topoisomerases, Type II
"DNA Topoisomerases, Type II" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex.
| Descriptor ID |
D004250
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| MeSH Number(s) |
D08.811.399.403.741
|
| Concept/Terms |
DNA Topoisomerases, Type II- DNA Topoisomerases, Type II
- Type II DNA Topoisomerase
- Topoisomerase II
- DNA Topoisomerase (ATP-Hydrolysing)
- DNA Topoisomerase II
- DNA Type 2 Topoisomerase
|
Below are MeSH descriptors whose meaning is more general than "DNA Topoisomerases, Type II".
Below are MeSH descriptors whose meaning is more specific than "DNA Topoisomerases, Type II".
This graph shows the total number of publications written about "DNA Topoisomerases, Type II" by people in this website by year, and whether "DNA Topoisomerases, Type II" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 1 | 2 |
| 1997 | 2 | 0 | 2 |
| 1998 | 1 | 1 | 2 |
| 1999 | 1 | 0 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 2 | 2 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2023 | 0 | 2 | 2 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "DNA Topoisomerases, Type II" by people in Profiles.
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The acidic C-terminal tail of DNA Gyrase of Salmonella enterica serovar Typhi controls DNA relaxation in an acidic environment. Int J Biol Macromol. 2024 Mar; 261(Pt 1):129728.
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RAD54L2-mediated DNA damage avoidance pathway specifically preserves genome integrity in response to topoisomerase 2 poisons. Sci Adv. 2023 12 08; 9(49):eadi6681.
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Genome-Wide CRISPR Screens Reveal ZATT as a Synthetic Lethal Target of TOP2-Poison Etoposide That Can Act in a TDP2-Independent Pathway. Int J Mol Sci. 2023 Mar 31; 24(7).
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Molecular profiling of 6,892 colorectal cancer samples suggests different possible treatment options specific to metastatic sites. Cancer Biol Ther. 2015; 16(12):1726-37.
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Regulation of sister chromosome cohesion by the replication fork tracking protein SeqA. PLoS Genet. 2013; 9(8):e1003673.
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DNA-dependent protein kinase and ataxia telangiectasia mutated (ATM) promote cell survival in response to NK314, a topoisomerase IIa inhibitor. Mol Pharmacol. 2011 Aug; 80(2):321-7.
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Multifactorial approach to predicting resistance to anthracyclines. J Clin Oncol. 2011 Apr 20; 29(12):1578-86.
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Action at hooked or twisted-hooked DNA juxtapositions rationalizes unlinking preference of type-2 topoisomerases. J Mol Biol. 2010 Jul 30; 400(5):963-82.
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A phase I study of vorinostat in combination with idarubicin in relapsed or refractory leukaemia. Br J Haematol. 2010 Jul; 150(1):72-82.
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The why and how of DNA unlinking. Nucleic Acids Res. 2009 Feb; 37(3):661-71.