"DNA Gyrase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Gyrase binds to DNA as a heterotetramer consisting of two A and two B subunits. In the presence of ATP, gyrase is able to convert the relaxed circular DNA duplex into a superhelix. In the absence of ATP, supercoiled DNA is relaxed by DNA gyrase.
| Descriptor ID |
D027081
|
| MeSH Number(s) |
D08.811.399.403.741.149 D12.776.097.237
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "DNA Gyrase".
Below are MeSH descriptors whose meaning is more specific than "DNA Gyrase".
This graph shows the total number of publications written about "DNA Gyrase" by people in this website by year, and whether "DNA Gyrase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 1 | 1 | 2 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 0 | 2 | 2 |
| 2018 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 2 | 2 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "DNA Gyrase" by people in Profiles.
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Structural basis of DNA crossover capture by Escherichia coli DNA gyrase. Science. 2024 04 12; 384(6692):227-232.
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Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria. J Med Chem. 2020 07 23; 63(14):7773-7816.
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Isolation and Molecular Characterization of Tick-Borne Relapsing Fever Borrelia Infecting Ornithodoros (Pavlovskyella) verrucosus Ticks Collected in Ukraine. J Infect Dis. 2020 02 18; 221(5):804-811.
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Effective therapeutic regimens in two South Asian countries with high resistance to major Helicobacter pylori antibiotics. Antimicrob Resist Infect Control. 2019; 8:40.
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Detection of Tickborne Relapsing Fever Spirochete, Austin, Texas, USA. Emerg Infect Dis. 2018 11; 24(11):2003-2009.
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Emerging Helicobacter pylori levofloxacin resistance and novel genetic mutation in Nepal. BMC Microbiol. 2016 11 04; 16(1):256.
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Surveillance of Levofloxacin Resistance in Helicobacter pylori Isolates in Bogot?-Colombia (2009-2014). PLoS One. 2016; 11(7):e0160007.
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Improved allele-specific PCR assays for detection of clarithromycin and fluoroquinolone resistant of Helicobacter pylori in gastric biopsies: identification of N87I mutation in GyrA. Diagn Microbiol Infect Dis. 2015 Apr; 81(4):251-5.
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GyrB polymorphisms accurately assign invasive viridans group streptococcal species. J Clin Microbiol. 2014 Aug; 52(8):2905-12.
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Temporal interplay between efflux pumps and target mutations in development of antibiotic resistance in Escherichia coli. Antimicrob Agents Chemother. 2012 Apr; 56(4):1680-5.