"DNA Topoisomerase IV" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Topoisomerase IV binds to DNA as a heterotetramer consisting 2 parC and 2 parE subunits. Topoisomerase IV is a decatenating enzyme that resolves interlinked daughter chromosomes following DNA replication.
| Descriptor ID |
D027101
|
| MeSH Number(s) |
D08.811.399.403.741.224 D12.776.097.256
|
| Concept/Terms |
parC Protein- parC Protein
- parC Gene Product, Topo IV
- Topoisomerase IV Subunit A
- parC Gene Product
parE Protein- parE Protein
- parE Gene Product, Topo IV
- Topoisomerase IV Subunit B
- parE Gene Product
|
Below are MeSH descriptors whose meaning is more general than "DNA Topoisomerase IV".
Below are MeSH descriptors whose meaning is more specific than "DNA Topoisomerase IV".
This graph shows the total number of publications written about "DNA Topoisomerase IV" by people in this website by year, and whether "DNA Topoisomerase IV" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "DNA Topoisomerase IV" by people in Profiles.
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Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria. J Med Chem. 2020 07 23; 63(14):7773-7816.
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Antibacterial Resistance in Ureaplasma Species and Mycoplasma hominis Isolates from Urine Cultures in College-Aged Females. Antimicrob Agents Chemother. 2017 10; 61(10).
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Regulation of sister chromosome cohesion by the replication fork tracking protein SeqA. PLoS Genet. 2013; 9(8):e1003673.
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Temporal interplay between efflux pumps and target mutations in development of antibiotic resistance in Escherichia coli. Antimicrob Agents Chemother. 2012 Apr; 56(4):1680-5.
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Pharmacodynamics of moxifloxacin against a high inoculum of Escherichia coli in an in vitro infection model. J Antimicrob Chemother. 2009 Sep; 64(3):556-62.
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Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates. Antimicrob Agents Chemother. 2009 Jan; 53(1):235-41.
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Impact of drug-exposure intensity and duration of therapy on the emergence of Staphylococcus aureus resistance to a quinolone antimicrobial. J Infect Dis. 2007 Jun 15; 195(12):1818-27.
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Brevundimonas diminuta infections and its resistance to fluoroquinolones. J Antimicrob Chemother. 2005 Jun; 55(6):853-9.
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Activities of newer fluoroquinolones against ciprofloxacin-resistant Streptococcus pneumoniae. Antimicrob Agents Chemother. 2001 Jun; 45(6):1654-9.
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Assembly of the FtsZ ring at the central division site in the absence of the chromosome. Mol Microbiol. 1998 Jul; 29(2):491-503.