"Zinc Finger Protein Gli3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A zinc finger transcription factor that contains five CYS2-HIS2 ZINC FINGERS and binds to the GLI consensus sequence 5'-GGGTGGTC-3'. The full-length protein functions as a transcriptional activator whereas the truncated C-terminal form functions as a transcriptional repressor of the Sonic Hedgehog (Shh) signaling pathway; a balance between these two forms is critical for limb and digit development. GLI3 also plays a critical role in the differentiation and proliferation of CHONDROCYTES.
| Descriptor ID |
D000074290
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| MeSH Number(s) |
D12.776.260.522.875 D12.776.260.703.900 D12.776.930.375.875 D12.776.930.780.972
|
| Concept/Terms |
Zinc Finger Protein Gli3- Zinc Finger Protein Gli3
- Glioma-Associated Oncogene Family Zinc Finger 3 Protein
- Glioma Associated Oncogene Family Zinc Finger 3 Protein
- GLI-Kruppel Family Member 3 Protein
- GLI Kruppel Family Member 3 Protein
|
Below are MeSH descriptors whose meaning is more general than "Zinc Finger Protein Gli3".
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This graph shows the total number of publications written about "Zinc Finger Protein Gli3" by people in this website by year, and whether "Zinc Finger Protein Gli3" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Zinc Finger Protein Gli3" by people in Profiles.
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A switch from low to high Shh activity regulates establishment of limb progenitors and signaling centers. Dev Cell. 2014 Apr 28; 29(2):241-9.
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Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. PLoS One. 2013; 8(1):e53830.
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Glioma-associated oncogene homologue 3, a hedgehog transcription factor, is highly expressed in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma. Hum Pathol. 2011 Nov; 42(11):1643-52.
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Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev. 2009 Aug 15; 23(16):1910-28.
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Characterization of the interactions of human ZIC3 mutants with GLI3. Hum Mutat. 2008 Jan; 29(1):99-105.
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Acute lymphoblastic leukemia in a patient with Greig cephalopolysyndactyly and interstitial deletion of chromosome 7 del(7)(p11.2 p14) involving the GLI3 and ZNFN1A1 genes. Genes Chromosomes Cancer. 2005 Jan; 42(1):82-6.
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Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development. Dev Biol. 1996 Nov 25; 180(1):273-83.