"Sp Transcription Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of DNA-binding proteins that contain three ZINC FINGERS at their carboxy termini. They are transcription factors that have specificity for GC boxes.
| Descriptor ID |
D051703
|
| MeSH Number(s) |
D12.776.260.522.750 D12.776.930.375.750
|
| Concept/Terms |
Sp Transcription Factors- Sp Transcription Factors
- Transcription Factors, Sp
- Specificity Protein Transcription Factors
- Sephacryl Phosphocellulose Transcription Factors
|
Below are MeSH descriptors whose meaning is more general than "Sp Transcription Factors".
Below are MeSH descriptors whose meaning is more specific than "Sp Transcription Factors".
This graph shows the total number of publications written about "Sp Transcription Factors" by people in this website by year, and whether "Sp Transcription Factors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 1 | 0 | 1 |
| 2009 | 2 | 1 | 3 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Sp Transcription Factors" by people in Profiles.
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CDODA-Me decreases specificity protein transcription factors and induces apoptosis in bladder cancer cells through induction of reactive oxygen species. Urol Oncol. 2016 08; 34(8):337.e11-8.
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Histone hyperacetylation up-regulates protein kinase Cd in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson disease. J Biol Chem. 2014 Dec 12; 289(50):34743-67.
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Mechanism of metformin-dependent inhibition of mammalian target of rapamycin (mTOR) and Ras activity in pancreatic cancer: role of specificity protein (Sp) transcription factors. J Biol Chem. 2014 Oct 03; 289(40):27692-701.
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Induction of the transcriptional repressor ZBTB4 in prostate cancer cells by drug-induced targeting of microRNA-17-92/106b-25 clusters. Mol Cancer Ther. 2012 Sep; 11(9):1852-62.
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Chemopreventive effects of tolfenamic acid against esophageal tumorigenesis in rats. Invest New Drugs. 2012 Jun; 30(3):853-61.
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Tolfenamic acid decreases c-Met expression through Sp proteins degradation and inhibits lung cancer cells growth and tumor formation in orthotopic mice. Invest New Drugs. 2011 Feb; 29(1):41-51.
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Oncogenic microRNA-27a is a target for anticancer agent methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate in colon cancer cells. Int J Cancer. 2009 Oct 15; 125(8):1965-74.
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Tolfenamic acid inhibits esophageal cancer through repression of specificity proteins and c-Met. Carcinogenesis. 2009 Jul; 30(7):1193-201.
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Regulation of vascular endothelial growth factor receptor-1 expression by specificity proteins 1, 3, and 4 in pancreatic cancer cells. Cancer Res. 2007 Apr 01; 67(7):3286-94.