"Sp7 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An Sp transcription factor that contains three CYS2-HIS2 ZINC FINGERS. It binds to GC RICH SEQUENCES and performs an essential function in regulating gene expression for differentiation of OSTEOBLASTS. Mutations in the SP7 gene are associated with type 12 OSTEOGENESIS IMPERFECTA.
| Descriptor ID |
D000076182
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| MeSH Number(s) |
D12.776.260.522.750.937 D12.776.930.375.750.937
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Sp7 Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "Sp7 Transcription Factor".
This graph shows the total number of publications written about "Sp7 Transcription Factor" by people in this website by year, and whether "Sp7 Transcription Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Sp7 Transcription Factor" by people in Profiles.
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Beneficial effects of Lactobacillus reuteri 6475 on bone density in male mice is dependent on lymphocytes. Sci Rep. 2019 10 11; 9(1):14708.
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Development of the fetal bone marrow niche and regulation of HSC quiescence and homing ability by emerging osteolineage cells. Cell Rep. 2014 Oct 23; 9(2):581-90.
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Asfotase-a improves bone growth, mineralization and strength in mouse models of neurofibromatosis type-1. Nat Med. 2014 Aug; 20(8):904-10.
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Osterix and NO66 histone demethylase control the chromatin of Osterix target genes during osteoblast differentiation. J Bone Miner Res. 2014 Apr; 29(4):855-65.
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Haploinsufficiency of osterix in chondrocytes impairs skeletal growth in mice. Physiol Genomics. 2013 Oct 01; 45(19):917-23.
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Genetic evidence for the vital function of Osterix in cementogenesis. J Bone Miner Res. 2012 May; 27(5):1080-92.
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Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice. Proc Natl Acad Sci U S A. 2010 Jul 20; 107(29):12919-24.
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Inhibition of Wnt signaling by the osteoblast-specific transcription factor Osterix. Proc Natl Acad Sci U S A. 2008 May 13; 105(19):6936-41.