"Sp7 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An Sp transcription factor that contains three CYS2-HIS2 ZINC FINGERS. It binds to GC RICH SEQUENCES and performs an essential function in regulating gene expression for differentiation of OSTEOBLASTS. Mutations in the SP7 gene are associated with type 12 OSTEOGENESIS IMPERFECTA.
| Descriptor ID |
D000076182
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| MeSH Number(s) |
D12.776.260.522.750.937 D12.776.930.375.750.937
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Sp7 Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "Sp7 Transcription Factor".
This graph shows the total number of publications written about "Sp7 Transcription Factor" by people in this website by year, and whether "Sp7 Transcription Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Sp7 Transcription Factor" by people in Profiles.
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Beneficial effects of Lactobacillus reuteri 6475 on bone density in male mice is dependent on lymphocytes. Sci Rep. 2019 10 11; 9(1):14708.
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Osterix functions downstream of anti-M?llerian hormone signaling to regulate M?llerian duct regression. Proc Natl Acad Sci U S A. 2018 08 14; 115(33):8382-8387.
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Hes4: A potential prognostic biomarker for newly diagnosed patients with high-grade osteosarcoma. Pediatr Blood Cancer. 2017 05; 64(5).
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Thymidine phosphorylase exerts complex effects on bone resorption and formation in myeloma. Sci Transl Med. 2016 08 24; 8(353):353ra113.
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Mesenchymal Deletion of Histone Demethylase NO66 in Mice Promotes Bone Formation. J Bone Miner Res. 2015 Sep; 30(9):1608-17.
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Mesenchyme-specific overexpression of nucleolar protein 66 in mice inhibits skeletal growth and bone formation. FASEB J. 2015 Jun; 29(6):2555-65.
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Development of the fetal bone marrow niche and regulation of HSC quiescence and homing ability by emerging osteolineage cells. Cell Rep. 2014 Oct 23; 9(2):581-90.
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Asfotase-a improves bone growth, mineralization and strength in mouse models of neurofibromatosis type-1. Nat Med. 2014 Aug; 20(8):904-10.
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Osterix and NO66 histone demethylase control the chromatin of Osterix target genes during osteoblast differentiation. J Bone Miner Res. 2014 Apr; 29(4):855-65.
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Haploinsufficiency of osterix in chondrocytes impairs skeletal growth in mice. Physiol Genomics. 2013 Oct 01; 45(19):917-23.