"Sp3 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A specificity protein transcription factor that contains three C-terminal CYS2-HIS2 ZINC FINGERS. It regulates expression of a variety of genes including VASCULAR ENDOTHELIAL GROWTH FACTOR and CYCLIN-DEPENDENT KINASE INHIBITOR P27.
| Descriptor ID |
D051705
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| MeSH Number(s) |
D12.776.260.522.750.750 D12.776.930.375.750.750
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Sp3 Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "Sp3 Transcription Factor".
This graph shows the total number of publications written about "Sp3 Transcription Factor" by people in this website by year, and whether "Sp3 Transcription Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2005 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
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Below are the most recent publications written about "Sp3 Transcription Factor" by people in Profiles.
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An Sp1/Sp3 binding polymorphism confers methylation protection. PLoS Genet. 2008 Aug 22; 4(8):e1000162.
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Association of NRH:quinone oxidoreductase 2 gene promoter polymorphism with higher gene expression and increased susceptibility to Parkinson's disease. J Gerontol A Biol Sci Med Sci. 2008 Feb; 63(2):127-34.
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Increased expression of integrin beta1 subunit enhances p21WAF1/Cip1 transcription through the Sp1 sites and p300-mediated histone acetylation in human hepatocellular carcinoma cells. J Cell Biochem. 2007 Jun 01; 101(3):654-64.
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Regulation of vascular endothelial growth factor receptor-1 expression by specificity proteins 1, 3, and 4 in pancreatic cancer cells. Cancer Res. 2007 Apr 01; 67(7):3286-94.
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Regulation of the Rhox5 homeobox gene in primary granulosa cells: preovulatory expression and dependence on SP1/SP3 and GABP. Biol Reprod. 2005 Dec; 73(6):1126-34.
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Identification of a novel SP3 binding site in the promoter of human IGFBP4 gene: role of SP3 and AP-1 in regulating promoter activity in CaCo2 cells. Oncogene. 2004 Apr 01; 23(14):2454-64.
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Cathepsin L gene expression and promoter activation in rodent granulosa cells. Endocrinology. 2004 Feb; 145(2):582-91.
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Egr-1 induction in rat granulosa cells by follicle-stimulating hormone and luteinizing hormone: combinatorial regulation by transcription factors cyclic adenosine 3',5'-monophosphate regulatory element binding protein, serum response factor, sp1, and early growth response factor-1. Mol Endocrinol. 2003 Apr; 17(4):520-33.
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Sp1 is essential for estrogen receptor alpha gene transcription. J Steroid Biochem Mol Biol. 2002 Sep; 82(1):7-18.
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Constitutive Sp1 activity is essential for differential constitutive expression of vascular endothelial growth factor in human pancreatic adenocarcinoma. Cancer Res. 2001 May 15; 61(10):4143-54.