Methylenetetrahydrofolate Dehydrogenase (NADP)
"Methylenetetrahydrofolate Dehydrogenase (NADP)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An NADP-dependent oxidoreductase that catalyses the conversion of 5,10-methyleneterahydrofolate to 5,10-methenyl-tetrahydrofolate. In higher eukaryotes a trifunctional enzyme exists with additional METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE and FORMATE-TETRAHYDROFOLATE LIGASE activity. The enzyme plays an important role in the synthesis of 5-methyltetrahydrofolate, the methyl donor for the VITAMIN B12-dependent remethylation of HOMOCYSTEINE to METHIONINE via METHIONINE SYNTHETASE.
| Descriptor ID |
D008754
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| MeSH Number(s) |
D08.811.682.662.253
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Methylenetetrahydrofolate Dehydrogenase (NADP)".
Below are MeSH descriptors whose meaning is more specific than "Methylenetetrahydrofolate Dehydrogenase (NADP)".
This graph shows the total number of publications written about "Methylenetetrahydrofolate Dehydrogenase (NADP)" by people in this website by year, and whether "Methylenetetrahydrofolate Dehydrogenase (NADP)" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Methylenetetrahydrofolate Dehydrogenase (NADP)" by people in Profiles.
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Optical coherence tomography-guided Brillouin microscopy highlights regional tissue stiffness differences during anterior neural tube closure in the Mthfd1l murine mutant. Development. 2024 May 15; 151(10).
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Formate concentrations in maternal plasma during pregnancy and in cord blood in a cohort of pregnant Canadian women: relations to genetic polymorphisms and plasma metabolites. Am J Clin Nutr. 2019 11 01; 110(5):1131-1137.
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MTHFD2 links RNA methylation to metabolic reprogramming in renal cell carcinoma. Oncogene. 2019 08; 38(34):6211-6225.
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Modulation of Redox Homeostasis by Inhibition of MTHFD2 in Colorectal Cancer: Mechanisms and Therapeutic Implications. J Natl Cancer Inst. 2019 Jun 01; 111(6):584-596.
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Nuclear enrichment of folate cofactors and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) protect de novo thymidylate biosynthesis during folate deficiency. J Biol Chem. 2014 Oct 24; 289(43):29642-50.
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Maternal and infant gene-folate interactions and the risk of neural tube defects. Am J Med Genet A. 2012 Oct; 158A(10):2439-46.
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Maternal vitamin use, genetic variation of infant methylenetetrahydrofolate reductase, and risk for spina bifida. Am J Epidemiol. 1998 Jul 01; 148(1):30-7.
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Increased activity of renal glycine-cleavage-enzyme complex in metabolic acidosis. Biochem J. 1985 Oct 15; 231(2):477-80.