Tetrahydrofolate Dehydrogenase
"Tetrahydrofolate Dehydrogenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. (Dorland, 27th ed) EC 1.5.1.3.
| Descriptor ID |
D013762
|
| MeSH Number(s) |
D08.811.682.662.825
|
| Concept/Terms |
Tetrahydrofolate Dehydrogenase- Tetrahydrofolate Dehydrogenase
- Dehydrogenase, Tetrahydrofolate
- Folic Acid Reductase
- Acid Reductase, Folic
- Reductase, Folic Acid
- Dihydrofolate Dehydrogenase
- Dehydrogenase, Dihydrofolate
- Dihydrofolate Reductase
- Reductase, Dihydrofolate
|
Below are MeSH descriptors whose meaning is more general than "Tetrahydrofolate Dehydrogenase".
Below are MeSH descriptors whose meaning is more specific than "Tetrahydrofolate Dehydrogenase".
This graph shows the total number of publications written about "Tetrahydrofolate Dehydrogenase" by people in this website by year, and whether "Tetrahydrofolate Dehydrogenase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Tetrahydrofolate Dehydrogenase" by people in Profiles.
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Methotrexate-based PROTACs as DHFR-specific chemical probes. Cell Chem Biol. 2024 Feb 15; 31(2):221-233.e14.
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Detecting Protein-Protein Interaction Based on Protein Fragment Complementation Assay. Curr Protein Pept Sci. 2020; 21(6):598-610.
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Genetic ablation of purine salvage in Cryptosporidium parvum reveals nucleotide uptake from the host cell. Proc Natl Acad Sci U S A. 2019 10 15; 116(42):21160-21165.
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Using a Dihydrofolate Reductase-Based Strategy for Producing the Biosimilar Version of Pertuzumab in CHO-S Cells. Monoclon Antib Immunodiagn Immunother. 2018 Feb; 37(1):26-37.
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Why sulfonamides are contraindicated in Rocky Mountain spotted fever. Dermatol Online J. 2014 Feb 18; 20(2).
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Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation. J Clin Invest. 2010 May; 120(5):1603-16.
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Estimating equation-based causality analysis with application to microarray time series data. Biostatistics. 2009 Jul; 10(3):468-80.
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Expression and prognostic significance of a panel of tissue hypoxia markers in head-and-neck squamous cell carcinomas. Int J Radiat Oncol Biol Phys. 2007 Sep 01; 69(1):167-75.
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Protection of hematopoietic stem cells from pemetrexed toxicity by retroviral gene transfer with a mutant dihydrofolate reductase-mutant thymidylate synthase fusion gene. Cancer Gene Ther. 2004 Dec; 11(12):767-73.
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A fluorine-labeled methotrexate as a probe for monitoring tumor antifolate pharmacokinetics: synthesis, in vitro cytotoxicity, and pilot in vivo 19F magnetic resonance spectra. Mol Cancer Ther. 2003 Oct; 2(10):933-9.