"Folic Acid Deficiency" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)
| Descriptor ID |
D005494
|
| MeSH Number(s) |
C18.654.521.500.133.699.308
|
| Concept/Terms |
Folic Acid Deficiency- Folic Acid Deficiency
- Deficiency, Folic Acid
- Acid Deficiencies, Folic
- Acid Deficiency, Folic
- Deficiencies, Folic Acid
- Folic Acid Deficiencies
|
Below are MeSH descriptors whose meaning is more general than "Folic Acid Deficiency".
Below are MeSH descriptors whose meaning is more specific than "Folic Acid Deficiency".
This graph shows the total number of publications written about "Folic Acid Deficiency" by people in this website by year, and whether "Folic Acid Deficiency" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2005 | 2 | 2 | 4 |
| 2006 | 3 | 0 | 3 |
| 2007 | 2 | 0 | 2 |
| 2008 | 2 | 1 | 3 |
| 2011 | 1 | 1 | 2 |
| 2012 | 1 | 1 | 2 |
| 2013 | 1 | 1 | 2 |
| 2014 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 1 | 2 |
| 2020 | 2 | 0 | 2 |
| 2024 | 1 | 3 | 4 |
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Below are the most recent publications written about "Folic Acid Deficiency" by people in Profiles.
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CIC de novo loss of function variants contribute to cerebral folate deficiency by downregulating FOLR1 expression. J Med Genet. 2021 07; 58(7):484-494.
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One-carbon metabolism and folate transporter genes: Do they factor prominently in the genetic etiology of neural tube defects? Biochimie. 2020 Jun; 173:27-32.
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Maternal Lactase Polymorphism (rs4988235) Is Associated with Neural Tube Defects in Offspring in the National Birth Defects Prevention Study. J Nutr. 2019 02 01; 149(2):295-303.
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C5a receptor signaling prevents folate deficiency-induced neural tube defects in mice. J Immunol. 2013 Apr 01; 190(7):3493-9.
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Periconceptional folate deficiency and implications in neural tube defects. J Pregnancy. 2012; 2012:295083.
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Anemia in at-risk populations--what should be our focus? Am J Clin Nutr. 2008 Dec; 88(6):1457-8.
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Use of a novel genetic mouse model to investigate the role of folate in colitis-associated colon cancer. J Nutr Biochem. 2009 Aug; 20(8):649-55.
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S-adenosylmethionine attenuates oxidative liver injury in micropigs fed ethanol with a folate-deficient diet. Alcohol Clin Exp Res. 2007 Nov; 31(11):1934-43.
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Spinal fluid 5-methyltetrahydrofolate levels are normal in Rett syndrome. Neurology. 2005 Jun 28; 64(12):2151-2.