NAV1.7 Voltage-Gated Sodium Channel
"NAV1.7 Voltage-Gated Sodium Channel" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A voltage-gated sodium channel subtype found widely expressed in nociceptive primary sensory neurons. Defects in the SCN9A gene, which codes for the alpha subunit of this sodium channel, are associated with several pain sensation-related disorders.
| Descriptor ID |
D062556
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| MeSH Number(s) |
D12.776.157.530.400.875.750.700 D12.776.543.550.450.875.750.700 D12.776.543.585.400.875.750.700 D12.776.631.960.700
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| Concept/Terms |
NAV1.7 Voltage-Gated Sodium Channel- NAV1.7 Voltage-Gated Sodium Channel
- NAV1.7 Voltage Gated Sodium Channel
- Voltage-Gated Sodium Channel Type 9
- Voltage Gated Sodium Channel Type 9
- Peripheral Sodium Channel 1
- Type 9 Voltage-Gated Sodium Channel
- Type 9 Voltage Gated Sodium Channel
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Below are MeSH descriptors whose meaning is more general than "NAV1.7 Voltage-Gated Sodium Channel".
Below are MeSH descriptors whose meaning is more specific than "NAV1.7 Voltage-Gated Sodium Channel".
This graph shows the total number of publications written about "NAV1.7 Voltage-Gated Sodium Channel" by people in this website by year, and whether "NAV1.7 Voltage-Gated Sodium Channel" was a major or minor topic of these publications.
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Below are the most recent publications written about "NAV1.7 Voltage-Gated Sodium Channel" by people in Profiles.
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DRG Voltage-Gated Sodium Channel 1.7 Is Upregulated in Paclitaxel-Induced Neuropathy in Rats and in Humans with Neuropathic Pain. J Neurosci. 2018 01 31; 38(5):1124-1136.
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Discovery of aminocyclohexene analogues as selective and orally bioavailable hNav1.7 inhibitors for analgesia. Bioorg Med Chem Lett. 2017 11 15; 27(22):4979-4984.
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The discovery of tetrahydropyridine analogs as hNav1.7 selective inhibitors for analgesia. Bioorg Med Chem Lett. 2017 05 15; 27(10):2210-2215.
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Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors. J Med Chem. 2016 09 08; 59(17):7818-39.