NAV1.2 Voltage-Gated Sodium Channel
"NAV1.2 Voltage-Gated Sodium Channel" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A voltage-gated sodium channel subtype that mediates the sodium ion permeability of excitable membranes. Defects in the SCN2A gene which codes for the alpha subunit of this sodium channel are associated with benign familial infantile seizures type 3, and early infantile epileptic encephalopathy type 11.
| Descriptor ID |
D062551
|
| MeSH Number(s) |
D12.776.157.530.400.875.750.200 D12.776.543.550.450.875.750.200 D12.776.543.585.400.875.750.200 D12.776.631.960.200
|
| Concept/Terms |
NAV1.2 Voltage-Gated Sodium Channel- NAV1.2 Voltage-Gated Sodium Channel
- NAV1.2 Voltage Gated Sodium Channel
- Type 2 Voltage-Gated Sodium Channel
- Type 2 Voltage Gated Sodium Channel
- Voltage-Gated Sodium Channel Type 2
- Voltage Gated Sodium Channel Type 2
Voltage-Gated Sodium Channel Type 2 Subunit alpha- Voltage-Gated Sodium Channel Type 2 Subunit alpha
- Voltage Gated Sodium Channel Type 2 Subunit alpha
- Voltage-Gated Sodium Channel Type 2 alpha Subunit
- Voltage Gated Sodium Channel Type 2 alpha Subunit
- Sodium Channel, Voltage-Gated, Type II, alpha 1 Subunit
- Sodium Channel Protein Type 2 Subunit alpha
- Sodium Channel, Voltage-Gated, Type II, alpha 1
- NAV1.2 alpha Subunit
- SCN2A Sodium Channel alpha Subunit
|
Below are MeSH descriptors whose meaning is more general than "NAV1.2 Voltage-Gated Sodium Channel".
Below are MeSH descriptors whose meaning is more specific than "NAV1.2 Voltage-Gated Sodium Channel".
This graph shows the total number of publications written about "NAV1.2 Voltage-Gated Sodium Channel" by people in this website by year, and whether "NAV1.2 Voltage-Gated Sodium Channel" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "NAV1.2 Voltage-Gated Sodium Channel" by people in Profiles.
-
Pharmacological Inhibition of Wee1 Kinase Selectively Modulates the Voltage-Gated Na+ Channel 1.2 Macromolecular Complex. Cells. 2021 11 10; 10(11).
-
An Ankyrin-G N-terminal Gate and Protein Kinase CK2 Dually Regulate Binding of Voltage-gated Sodium and KCNQ2/3 Potassium Channels. J Biol Chem. 2015 Jul 03; 290(27):16619-32.
-
Clinical whole-genome sequencing in severe early-onset epilepsy reveals new genes and improves molecular diagnosis. Hum Mol Genet. 2014 Jun 15; 23(12):3200-11.
-
Disruption of the SCN2A and SCN3A genes in a patient with mental retardation, neurobehavioral and psychiatric abnormalities, and a history of infantile seizures. Clin Genet. 2011 Aug; 80(2):191-5.
-
Where is the spike generator of the cochlear nerve? Voltage-gated sodium channels in the mouse cochlea. J Neurosci. 2005 Jul 20; 25(29):6857-68.