NAV1.1 Voltage-Gated Sodium Channel
"NAV1.1 Voltage-Gated Sodium Channel" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A voltage-gated sodium channel subtype that is predominantly expressed in the CENTRAL NERVOUS SYSTEM. Defects in the SCN1A gene which codes for the alpha subunit of this sodium channel are associated with DRAVET SYNDROME, generalized epilepsy with febrile seizures plus, type 2 (GEFS+2), and familial hemiplegic migraine type 3.
| Descriptor ID |
D062550
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| MeSH Number(s) |
D12.776.157.530.400.875.750.100 D12.776.543.550.450.875.750.100 D12.776.543.585.400.875.750.100 D12.776.631.960.100
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| Concept/Terms |
NAV1.1 Voltage-Gated Sodium Channel- NAV1.1 Voltage-Gated Sodium Channel
- NAV1.1 Voltage Gated Sodium Channel
- Voltage-Gated Sodium Channel Type 1
- Voltage Gated Sodium Channel Type 1
- Type 1 Voltage-Gated Sodium Channel
- Type 1 Voltage Gated Sodium Channel
Voltage-Gated Sodium Channel Type 1 Subunit alpha- Voltage-Gated Sodium Channel Type 1 Subunit alpha
- Voltage Gated Sodium Channel Type 1 Subunit alpha
- Sodium Channel, Voltage-Gated, Type I, alpha Protein
- SCN1A Sodium Channel alpha Subunit
- Voltage-Gated Sodium Channel Type 1 alpha Subunit
- Voltage Gated Sodium Channel Type 1 alpha Subunit
- NAV1.1 alpha Subunit
- alpha Subunit, NAV1.1
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Below are MeSH descriptors whose meaning is more general than "NAV1.1 Voltage-Gated Sodium Channel".
Below are MeSH descriptors whose meaning is more specific than "NAV1.1 Voltage-Gated Sodium Channel".
This graph shows the total number of publications written about "NAV1.1 Voltage-Gated Sodium Channel" by people in this website by year, and whether "NAV1.1 Voltage-Gated Sodium Channel" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 2 | 1 | 3 |
| 2016 | 0 | 1 | 1 |
| 2019 | 1 | 1 | 2 |
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "NAV1.1 Voltage-Gated Sodium Channel" by people in Profiles.
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A hyperthermic seizure unleashes a surge of spreading depolarizations in Scn1a-deficient mice. JCI Insight. 2023 08 08; 8(15).
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The gain of function SCN1A disorder spectrum: novel epilepsy phenotypes and therapeutic implications. Brain. 2022 11 21; 145(11):3816-3831.
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Predicting the impact of sodium channel mutations in human brain disease. Epilepsia. 2019 12; 60 Suppl 3:S8-S16.
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Home-cage monitoring ascertains signatures of ictal and interictal behavior in mouse models of generalized seizures. PLoS One. 2019; 14(11):e0224856.
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Sudden unexpected death in epilepsy genetics: Molecular diagnostics and prevention. Epilepsia. 2016 Jan; 57 Suppl 1:17-25.
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High-resolution molecular genomic autopsy reveals complex sudden unexpected death in epilepsy risk profile. Epilepsia. 2014 Feb; 55(2):e6-12.
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Na+ channel-dependent recruitment of Nav?4 to axon initial segments and nodes of Ranvier. J Neurosci. 2013 Apr 03; 33(14):6191-202.
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Authors' response to correspondence on "mesial temporal sclerosis in a cohort of children with SCN1A gene mutation". J Child Neurol. 2013 Apr; 28(4):542.
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Mesial temporal sclerosis in a cohort of children with SCN1A gene mutation. J Child Neurol. 2012 Jul; 27(7):893-7.
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Multiplexed transposon-mediated stable gene transfer in human cells. Proc Natl Acad Sci U S A. 2010 Jan 26; 107(4):1343-8.