NAV1.5 Voltage-Gated Sodium Channel
"NAV1.5 Voltage-Gated Sodium Channel" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A voltage-gated sodium channel subtype that mediates the sodium ion PERMEABILITY of CARDIOMYOCYTES. Defects in the SCN5A gene, which codes for the alpha subunit of this sodium channel, are associated with a variety of CARDIAC DISEASES that result from loss of sodium channel function.
| Descriptor ID |
D062554
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| MeSH Number(s) |
D12.776.157.530.400.875.750.500 D12.776.543.550.450.875.750.500 D12.776.543.585.400.875.750.500 D12.776.631.960.500
|
| Concept/Terms |
NAV1.5 Voltage-Gated Sodium Channel- NAV1.5 Voltage-Gated Sodium Channel
- NAV1.5 Voltage Gated Sodium Channel
- Voltage-Gated Sodium Channel Type 5
- Voltage Gated Sodium Channel Type 5
- Type 5 Voltage-Gated Sodium Channel
- Type 5 Voltage Gated Sodium Channel
Voltage-Gated Sodium Channel Type 5 Subunit alpha- Voltage-Gated Sodium Channel Type 5 Subunit alpha
- Voltage Gated Sodium Channel Type 5 Subunit alpha
- SCN5A Sodium Channel alpha Subunit
- Voltage-Gated Na+ Channel Na(v)1.5a
- Sodium Channel Protein Type 5 Subunit alpha
- Sodium Channel, Voltage-Gated, Type V, alpha Subunit
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Below are MeSH descriptors whose meaning is more general than "NAV1.5 Voltage-Gated Sodium Channel".
Below are MeSH descriptors whose meaning is more specific than "NAV1.5 Voltage-Gated Sodium Channel".
This graph shows the total number of publications written about "NAV1.5 Voltage-Gated Sodium Channel" by people in this website by year, and whether "NAV1.5 Voltage-Gated Sodium Channel" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 2 | 2 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2007 | 0 | 2 | 2 |
| 2009 | 0 | 2 | 2 |
| 2010 | 0 | 2 | 2 |
| 2011 | 0 | 2 | 2 |
| 2012 | 2 | 0 | 2 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 1 | 2 |
| 2018 | 2 | 0 | 2 |
| 2019 | 2 | 0 | 2 |
| 2020 | 0 | 1 | 1 |
| 2021 | 1 | 1 | 2 |
| 2023 | 1 | 0 | 1 |
| 2024 | 2 | 0 | 2 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "NAV1.5 Voltage-Gated Sodium Channel" by people in Profiles.
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Molecular interactions of the NaV1.5 C-terminal domain: CaM sequestered the IQ motif from the CTD. J Biol Chem. 2025 12; 301(12):110871.
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An all-atom model of the human cardiac sodium channel in a lipid bilayer. Sci Rep. 2024 11 06; 14(1):26857.
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Rescue of Scn5a mis-splicing does not improve the structural and functional heart defects of a DM1 heart mouse model. Hum Mol Genet. 2024 10 07; 33(20):1789-1799.
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Pediatric and Familial Genetic Arrhythmia Syndromes: SCN5A-Related Disorders When It Is Not Long QT Type 3: Clinical Signs and Symptoms. Card Electrophysiol Clin. 2024 06; 16(2):211-218.
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Antiarrhythmic Hit to Lead Refinement in a Dish Using Patient-Derived iPSC Cardiomyocytes. J Med Chem. 2021 05 13; 64(9):5384-5403.
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Development of Allosteric Modulators of Voltage-Gated Na+ Channels: A Novel Approach for an Old Target. Curr Top Med Chem. 2021; 21(10):841-848.
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Epigenomic and Transcriptomic Dynamics During Human Heart Organogenesis. Circ Res. 2020 10 09; 127(9):e184-e209.
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Validation and Disease Risk Assessment of Previously Reported Genome-Wide Genetic Variants Associated With Brugada Syndrome: SADS-TW BrS Registry. Circ Genom Precis Med. 2020 08; 13(4):e002797.
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Multiple SCN5A variant enhancers modulate its cardiac gene expression and the QT interval. Proc Natl Acad Sci U S A. 2019 05 28; 116(22):10636-10645.
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Protein Phosphatase 2A Regulates Cardiac Na+ Channels. Circ Res. 2019 03; 124(5):737-746.