Promyelocytic Leukemia Zinc Finger Protein
"Promyelocytic Leukemia Zinc Finger Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A Krupple-type transcription factor consisting of an N-terminal BTB DOMAIN and nine CYS2-HIS2 ZINC FINGERS. It localizes to the nucleus and regulates cell cycle progression and gene expression for tissue development and homeostasis; it may also function as an epigenetic regulator through its interactions with HISTONE DEACETYLASE. Genetic rearrangements involving the ZBTB16 gene are associated with ACUTE PROMYELOCYTIC LEUKEMIA.
| Descriptor ID |
D000075722
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| MeSH Number(s) |
D12.776.260.522.625 D12.776.930.375.625
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Promyelocytic Leukemia Zinc Finger Protein".
Below are MeSH descriptors whose meaning is more specific than "Promyelocytic Leukemia Zinc Finger Protein".
This graph shows the total number of publications written about "Promyelocytic Leukemia Zinc Finger Protein" by people in this website by year, and whether "Promyelocytic Leukemia Zinc Finger Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Promyelocytic Leukemia Zinc Finger Protein" by people in Profiles.
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Non-cytotoxic Cardiac Innate Lymphoid Cells Are a Resident and Quiescent Type 2-Commited Population. Front Immunol. 2019; 10:634.
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Using CRISPR/Cas9 engineering to generate a mouse with a conditional knockout allele for the promyelocytic leukemia zinc finger transcription factor. Genesis. 2019 03; 57(3):e23281.
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Human endometrial stromal cell decidualization requires transcriptional reprogramming by PLZF. Biol Reprod. 2018 01 01; 98(1):15-27.
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The Lysine Acetyltransferase GCN5 Is Required for iNKT Cell Development through EGR2 Acetylation. Cell Rep. 2017 07 18; 20(3):600-612.
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The Promyelocytic Leukemia Zinc Finger Transcription Factor Is Critical for Human Endometrial Stromal Cell Decidualization. PLoS Genet. 2016 Apr; 12(4):e1005937.
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Innate PLZF+CD4+ a? T cells develop and expand in the absence of Itk. J Immunol. 2014 Jul 15; 193(2):673-87.
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Dynamic Hedgehog signalling pathway activity in germline stem cells. Andrology. 2014 Mar; 2(2):267-74.
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The fate of spermatogonial stem cells in the cryptorchid testes of RXFP2 deficient mice. PLoS One. 2013; 8(10):e77351.
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Leukemia translocation protein PLZF inhibits cell growth and expression of cyclin A. Oncogene. 1999 Jan 28; 18(4):925-34.
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Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein. Oncogene. 1998 May 14; 16(19):2549-56.