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CHELLAKKAN BLESSON

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Obstetrics & Gynecology
Address1102 BATES
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    I am a reproductive biologist specialized in reproductive endocrinology and metabolism. I have vast experience in the field of sex hormone signaling and its relevance in reproduction and metabolism. I am involved in translational research and teaching. I am passionate about applying my research expertise to improve health care. I also teach and mentor residents and fellows.

    My research team is working towards understanding the developmental origins of diseases and its role in reproduction and metabolism. Developmental programming is a recent concept whereby adverse environment during critical periods of early development predisposes the organism to increased risk of metabolic diseases in adult life. We are currently investigating the roles of hormones and nutrition during early development and its implication in the developmental origin of polycystic ovary syndrome (PCOS) and type 2 diabetes respectively.

    We use mouse PCOS models to investigate the effects of the disease on ovary, oocytes and embryos. We are currently studying the role of androgens in mitochondrial function and metabolism. We also recently developed a novel low protein programmed lean type 2 diabetic rat model to investigate the role of developmental programming of type 2 diabetes.

    Our team is also involved in improving quality and developing novel technologies to assist in fertility treatments. My lab’s mission is to improve reproductive success by (i) bringing new cutting edge assisted reproductive technologies and to apply it to our patients, (ii) to better understand the mechanisms of reproductive diseases and (iii) to foster an environment of knowledge driven patient care and education in the center.

    Other than research and teaching, I also work as an andrologist and junior embryologist at the Family Fertility Center, Texas Children’s Hospital.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dominguez F, Blesson CS. Editorial: Single cell analysis in endocrinology, reproduction, and metabolism. Front Endocrinol (Lausanne). 2023; 14:1282987. PMID: 37941904; PMCID: PMC10627802.
      Citations:    Fields:    
    2. Hofmann A, Mishra JS, Yadav P, Dangudubiyyam SV, Blesson CS, Kumar S. PFOS Impairs Mitochondrial Biogenesis and Dynamics and Reduces Oxygen Consumption in Human Trophoblasts. J Environ Sci Public Health. 2023; 7(4):164-175. PMID: 37920428; PMCID: PMC10621633.
      Citations:    
    3. Mishra A, Betancourt A, Vidyadharan VA, Blesson CS, Belfort M, Yallampalli C, Chauhan M. Calcitonin gene-related peptide protects from soluble fms-like tyrosine kinase-1-induced vascular dysfunction in a preeclampsia mouse model. Front Physiol. 2023; 14:1221684. PMID: 37719463; PMCID: PMC10500126.
      Citations:    
    4. Dong Y, Vipin VA, Blesson CS, Yallampalli C. Impact of adrenomedullin on mitochondrial respiratory capacity in human adipocyte. Sci Rep. 2023 06 13; 13(1):9578. PMID: 37311963; PMCID: PMC10264416.
      Citations:    Fields:    Translation:HumansCells
    5. Vidyadharan VA, Blesson CS, Tanchico D, Betancourt A, Smith C, Yallampalli C. Low Protein Programming Causes Increased Mitochondrial Fusion and Decreased Oxygen Consumption in the Hepatocytes of Female Rats. Nutrients. 2023 Mar 24; 15(7). PMID: 37049409; PMCID: PMC10097083.
      Citations:    Fields:    Translation:AnimalsCells
    6. Dong Y, Vipin VA, Blesson CS, Yallampalli C. Impact of Adrenomedullin on Mitochondrial Respiratory Capacity in Human Adipocyte. Res Sq. 2023 Mar 06. PMID: 36945563; PMCID: PMC10029071.
      Citations:    
    7. Vipin VA, Blesson CS, Yallampalli C. Maternal low protein diet and fetal programming of lean type 2 diabetes. World J Diabetes. 2022 Mar 15; 13(3):185-202. PMID: 35432755; PMCID: PMC8984567.
      Citations:    
    8. Vidyadharan VA, Betancourt A, Smith C, Yallampalli C, Blesson CS. Prenatal Low-Protein Diet Affects Mitochondrial Structure and Function in the Skeletal Muscle of Adult Female Offspring. Nutrients. 2022 Mar 09; 14(6). PMID: 35334815; PMCID: PMC8954615.
      Citations:    Fields:    Translation:AnimalsCells
    9. Gannon AL, Chacko SK, Didelija IC, Marini JC, Blesson CS. Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model. J Vis Exp. 2022 03 05; (181). PMID: 35312673.
      Citations:    Fields:    Translation:Animals
    10. Chappell NR, Gibbons WE, Blesson CS. Pathology of hyperandrogenemia in the oocyte of polycystic ovary syndrome. Steroids. 2022 04; 180:108989. PMID: 35189133; PMCID: PMC8920773.
      Citations:    Fields:    Translation:HumansCells
    11. Barsky M, Merkison J, Hosseinzadeh P, Yang L, Bruno-Gaston J, Dunn J, Gibbons W, Blesson CS. Fetal programming of polycystic ovary syndrome: Effects of androgen exposure on prenatal ovarian development. J Steroid Biochem Mol Biol. 2021 03; 207:105830. PMID: 33515680; PMCID: PMC8056856.
      Citations: 4     Fields:    Translation:HumansAnimals
    12. Hosseinzadeh P, Barsky M, Gibbons WE, Blesson CS. Polycystic Ovary Syndrome and the Forgotten Uterus. F S Rev. 2021 Jan; 2(1):11-20. PMID: 34423324; PMCID: PMC8378802.
      Citations:    
    13. Chappell NR, Zhou B, Hosseinzadeh P, Schutt A, Gibbons WE, Blesson CS. Hyperandrogenemia alters mitochondrial structure and function in the oocytes of obese mouse with polycystic ovary syndrome. F S Sci. 2021 02; 2(1):101-112. PMID: 34458875; PMCID: PMC8392073.
      Citations: 3     Translation:HumansAnimalsCells
    14. Blesson CS, Schutt AK, Vipin VA, Tanchico DT, Mathew PR, Balakrishnan M, Betancourt A, Yallampalli C. In utero low-protein-diet-programmed type 2 diabetes in adult offspring is mediated by sex hormones in rats?. Biol Reprod. 2020 10 29; 103(5):1110-1120. PMID: 32766739; PMCID: PMC7609843.
      Citations: 2     Fields:    Translation:Animals
    15. Chappell NR, Barsky M, Shah J, Peavey M, Yang L, Sangi-Haghpeykar H, Gibbons W, Blesson CS. Embryos from polycystic ovary syndrome patients with hyperandrogenemia reach morula stage faster than controls. F S Rep. 2020 Sep; 1(2):125-132. PMID: 34223228; PMCID: PMC8244380.
      Citations: 5     
    16. Mishra JS, Blesson CS, Kumar S. Testosterone Decreases Placental Mitochondrial Content and Cellular Bioenergetics. Biology (Basel). 2020 Jul 20; 9(7). PMID: 32698476; PMCID: PMC7407169.
      Citations: 3     
    17. Barsky M, Blesson CS. Should we be worried about advanced paternal age? Fertil Steril. 2020 08; 114(2):259-260. PMID: 32624217.
      Citations:    Fields:    Translation:Humans
    18. Chappell NR, Zhou B, Schutt AK, Gibbons WE, Blesson CS. Prenatal androgen induced lean PCOS impairs mitochondria and mRNA profiles in oocytes. Endocr Connect. 2020 Feb 01. PMID: 32101528; PMCID: PMC7159265.
      Citations: 9     
    19. Barsky M, Blesson CS. Oocytes, obesity, and omega-3 fatty acids. Fertil Steril. 2020 01; 113(1):71-72. PMID: 32033727; PMCID: PMC8211121.
      Citations:    Fields:    Translation:HumansCells
    20. Blesson CS, Schutt A, Chacko S, Marini JC, Mathew PR, Tanchico D, Balakrishnan M, Yallampalli C. Sex Dependent Dysregulation of Hepatic Glucose Production in Lean Type 2 Diabetic Rats. Front Endocrinol (Lausanne). 2019; 10:538. PMID: 31447783; PMCID: PMC6691354.
      Citations: 4     Fields:    
    21. Schutt AK, Blesson CS, Hsu JW, Valdes CT, Gibbons WE, Jahoor F, Yallampalli C. Preovulatory exposure to a protein-restricted diet disrupts amino acid kinetics and alters mitochondrial structure and function in the rat oocyte and is partially rescued by folic acid. Reprod Biol Endocrinol. 2019 Jan 17; 17(1):12. PMID: 30654812; PMCID: PMC6337842.
      Citations: 5     Fields:    Translation:AnimalsCells
    22. . Involvement of Gas6 protein in mouse model of lipopolysaccharide-induced lung inflammation. Biomedical and Biotechnology Research Journal. 2018; 2(2):146-151. View Publication.
    23. Chappell N.R, and BLESSON C.S . Endocrinology and Diabetes Open Access. Polycystic Ovary Syndrome: A Multifaceted Enigma. Endocrinology and Diabetes Open Access. 2018; 1(1). View Publication.
    24. Blesson CS, Schutt A, Mathew PR, Tanchico D, Balakrishnan M, Yallampalli U, Yallampalli C. Folate treatment partially reverses gestational low-protein diet-induced glucose intolerance and the magnitude of reversal is age and sex dependent. Nutrition. 2018 05; 49:81-89. PMID: 29500969; PMCID: PMC6918946.
      Citations: 2     Fields:    Translation:HumansAnimals
    25. Blesson CS, Chinnathambi V, Kumar S, Yallampalli C. Gestational Protein Restriction Impairs Glucose Disposal in the Gastrocnemius Muscles of Female Rats. Endocrinology. 2017 04 01; 158(4):756-767. PMID: 28324067; PMCID: PMC5460798.
      Citations: 6     Fields:    Translation:AnimalsCells
    26. Blesson CS, Schutt AK, Balakrishnan MP, Pautler RG, Pedersen SE, Sarkar P, Gonzales D, Zhu G, Marini JC, Chacko SK, Yallampalli U, Yallampalli C. Novel lean type 2 diabetic rat model using gestational low-protein programming. Am J Obstet Gynecol. 2016 Apr; 214(4):540.e1-540.e7. PMID: 26874300; PMCID: PMC4808600.
      Citations: 7     Fields:    Translation:Animals
    27. More AS, Mishra JS, Gopalakrishnan K, Blesson CS, Hankins GD, Sathishkumar K. Prenatal Testosterone Exposure Leads to Gonadal Hormone-Dependent Hyperinsulinemia and Gonadal Hormone-Independent Glucose Intolerance in Adult Male Rat Offspring. Biol Reprod. 2016 Jan; 94(1):5. PMID: 26586841; PMCID: PMC4809560.
      Citations: 6     Fields:    Translation:AnimalsCells
    28. Blesson CS, Yallampalli C. Pregnancy is a new window of susceptibility for bisphenol a exposure. Endocrinology. 2015 May; 156(5):1611-2. PMID: 25886069; PMCID: PMC4398767.
      Citations: 3     Fields:    Translation:AnimalsCellsPHPublic Health
    29. Blesson CS, Chinnathambi V, Hankins GD, Yallampalli C, Sathishkumar K. Prenatal testosterone exposure induces hypertension in adult females via androgen receptor-dependent protein kinase Cd-mediated mechanism. Hypertension. 2015 Mar; 65(3):683-690. PMID: 25489059; PMCID: PMC4326589.
      Citations: 15     Fields:    Translation:AnimalsCells
    30. Chauhan M, Balakrishnan M, Blesson CS, Yallampalli C. Adrenomedullin2 (ADM2)/intermedin (IMD) in rat ovary: changes in estrous cycle and pregnancy and its role in ovulation and steroidogenesis. Biol Reprod. 2015 Feb; 92(2):39. PMID: 25395681; PMCID: PMC4326727.
      Citations: 1     Fields:    Translation:AnimalsCells
    31. Chinnathambi V, Blesson CS, Vincent KL, Saade GR, Hankins GD, Yallampalli C, Sathishkumar K. Elevated testosterone levels during rat pregnancy cause hypersensitivity to angiotensin II and attenuation of endothelium-dependent vasodilation in uterine arteries. Hypertension. 2014 Aug; 64(2):405-14. PMID: 24842922; PMCID: PMC4096063.
      Citations: 23     Fields:    Translation:Animals
    32. . Receptors and Clinical Investigation. Prostaglandin E and F receptors in the uterus. 2014; 1(2). View Publication.
    33. Blesson CS, Sathishkumar K, Chinnathambi V, Yallampalli C. Gestational protein restriction impairs insulin-regulated glucose transport mechanisms in gastrocnemius muscles of adult male offspring. Endocrinology. 2014 Aug; 155(8):3036-46. PMID: 24797633; PMCID: PMC4098002.
      Citations: 15     Fields:    Translation:Animals
    34. Roos N, Blesson CS, Stephansson O, Masironi B, Vladic Stjernholm Y, Ekman-Ordeberg G, Sahlin L. The expression of prostaglandin receptors EP3 and EP4 in human cervix in post-term pregnancy differs between failed and successful labor induction. Acta Obstet Gynecol Scand. 2014 Feb; 93(2):159-67. PMID: 24180609.
      Citations: 2     Fields:    Translation:Humans
    35. . Expression and localization of prostaglandin receptors and stromal factors in human cervix—Variations in pregnant and non-pregnant states. Open Journal of Molecular and Integrative Physiology. 2013; 3(4). View Publication.
    36. Saxena R, Fatima I, Chandra V, Blesson CS, Kharkwal G, Hussain MK, Hajela K, Roy BG, Dwivedi A. Benzopyran derivative CDRI-85/287 induces G2-M arrest in estrogen receptor-positive breast cancer cells via modulation of estrogen receptors a- and ?-mediated signaling, in parallel to EGFR signaling and suppresses the growth of tumor xenograft. Steroids. 2013 Nov; 78(11):1071-86. PMID: 23891847.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    37. Blesson CS, Sahlin L. Expression pattern and signalling pathways in neutrophil like HL-60 cells after treatment with estrogen receptor selective ligands. Mol Cell Endocrinol. 2012 Sep 25; 361(1-2):179-90. PMID: 22554835.
      Citations: 6     Fields:    Translation:HumansCells
    38. BLESSON C.S, Masironi B and Sahlin L. . Effects of selective estrogen receptor agonists on estrogen receptor expression in the uterus of ovariectomized rats. Open Journal of Molecular and Integrative Physiology. 2012; 2:35-43. View Publication.
    39. Blesson CS, Masironi B, Sahlin L, B?ttner E. Prostaglandin receptors EP and FP are regulated by estradiol and progesterone in the uterus of ovariectomized rats. Reprod Biol Endocrinol. 2012 Jan 18; 10:3. PMID: 22257560; PMCID: PMC3278370.
      Citations: 4     Fields:    Translation:AnimalsCells
    40. . Estrogen Receptors in Leukocytes - Possible Impact on Inflammatory Processes in the Female Reproductive System. Update on Mechanisms of Hormone Action. 2011. View Publication.
    41. Vladic-Stjernholm Y, Vladic T, Blesson CS, Ekman-Ordeberg G, Sahlin L. Prostaglandin treatment is associated with a withdrawal of progesterone and androgen at the receptor level in the uterine cervix. Reprod Biol Endocrinol. 2009 Oct 23; 7:116. PMID: 19852793; PMCID: PMC2774313.
      Citations: 8     Fields:    Translation:HumansCellsCTClinical Trials
    42. Srinivasan KR, Blesson CS, Fatima I, Kitchlu S, Jain SK, Mehrotra PK, Dwivedi A. Expression of alphaVbeta3 integrin in rat endometrial epithelial cells and its functional role during implantation. Gen Comp Endocrinol. 2009 Jan 15; 160(2):124-33. PMID: 19027743.
      Citations: 8     Fields:    Translation:AnimalsCells
    43. Awasthi S, Blesson CS, Dwivedi A. Expression of oestrogen receptors alpha and beta during the period of uterine receptivity in rat: effect of ormeloxifene, a selective oestrogen receptor modulator. Acta Physiol (Oxf). 2007 Jan; 189(1):47-56. PMID: 17280556.
      Citations: 2     Fields:    Translation:Animals
    44. Blesson CS, Awasthi S, Kharkwal G, Daverey A, Dwivedi A. Modulation of estrogen receptor transactivation and estrogen-induced gene expression by ormeloxifene-a triphenylethylene derivative. Steroids. 2006 Nov; 71(11-12):993-1000. PMID: 16965798.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
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